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Single-cell subsets marker gene.md

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SINGLE CELL SUBTYPES' MARKERS

Some Gene-Protein pair

TNFRSF4:OX40
TNFRSF9:4-1BB
TNFRSF18:GITR

T

Naive(naive)

SELL(CD62L),CCR2,CCR7,ZBTB7B,CD27,S100A4

Exhausted(ex)

EOMES,CXCL13,PDCD1,TOX,LAYN,HAVCR2,LAG3,TIGIT,PRDM1(BLIMP1)

Anergic T

BTLA, RNF128(GRAIL), CBLB, ITCH, NEDD4

Effector(eff)

CX3CR1,GNLY,ITGAM,FGFBP2 CXCR3,CXCL10,CD44

Activated

IFNG,TNF,KLRC1

Effector memory(em)

GZMK,CCL4,CCL3L3,KLRD1,CD74

Tissue resident memory(rm)

ZNF683,FABP5,ITGA1,ITGAE,LITAF,CXCR6,CD69

Central memory(cm)

ANXA1,SELL,S1PR1,IL7R,CD44

Mucosal associatd invariant T(MAIT)

SCL4A10,KLRB1,ZBTB16,NCR3

Terminally differentiated effector cell(temra)

CX3CR1,NKG7,FGFBP2,PRF1,S1PR5

Memory(mem)

GPR183,CD69,KLF2,DUSP2,EOMES,KLRC1(decreased cytotoxic signature),CD27(CD4)

Suppressive Treg(aTreg)

CD4,CTLA4(CD152),CCR8,TNFRSF4,TNFRSF18(GITR),IL2RA,IL7R(CD127)

Natural Treg

ILRA(CD25), CTLA4,TNFRSF18(GITR),FOXP3, STAT5, FOXO1, FOXO3, IL35, IL10

iTreg

ILRA(CD25), CTLA4, TNFRSF18(GITR), FOXP3, STAT5, FOXO1, FOXO3, SMAD2, SMAD3, SMAD4, IL10

Resting Treg(rTreg)

RTKN2

Th1

BAX,SMAD2,IFNG,IL12RB1,CXCR3,TBX21(T-bet),STAT4,STAT1,IFNG,IL2,IL18

Th2

MIF,CCR4,IL2,IL4,SPI1(Pu.1),IL9,IL10

Th17

IL26,IL17,IL18,CD200,CD99,BTLA,IL1R1,STAT3,KLRB1(CD161)

Th22

CCR10

Follicular helper T(Tfh)

CD200,CXCR5,CD84,IL21,BCL6,CCR5,CD40LG(CD154),TNFSF4(OX40L),SLAMF1(SLAM),IL21R,PDCD1,STAT3

NKT

KLRB1,SLAMF1,SLAMF6,TGFBR1

gdT

IFNG, IL17A, IL17F, IL22

NK

KLRD1,KLRC1

B

CD79A,CD19, MS4A1(CD20,mature indicator)

Plasma

IGKC,JCHAIN,SDC1(CD138), SLAMF7, IGHG2, IGHGP, IGHA2, MZB1, DERL3, XBP1

Follicular B

CD83, CD69, SELL, BANK1

GC center B

HMGA1, AICDA, RGS13

Dendritic cell(DC)

CCL22, CD86, LAMP3

Myeloid DC(mDC)

ITGAX,ITGAM,ANPEP,CD33,CD14-,CD16-

plasmacytoid DC(pDC)

CLEC4C,BDCA2,BDCA4,IL3RA,IRF4,IRF8,IRF7,LILRB4,NRP1

Cancer marker

Basal cell carcinoma(BCC)

EPCAM,BCAM,TP63,KRT17

Cancer-associated fibroblast(CAF)

FAP,STC1,ASPN,S100A4,PDGFRB,DES,VIM,NG2

Pericyte

PDGFRB

Endothelial cell

VWF,PECAM1,PTPRB

Venous

EMCN,EPHB4,FLT4,LEFTY1,LEFTY2,NRP2

Arterial

EFNB2,NRP1,VEGF,EPAS

Lymphatic

LYVE1,VEGFR3,PROX1

Glomerular

AQP1,SEMA3G,CLDN5,SLC14A1,PLVAP

Descending vasa

KDR,AQP1,SEMA3G,CLDN5,SLC14A1

Ascending vasa

KDR,AQP1,SEMA3G,CLDN5,SLC14A1,PLVAP

High endothelial venule(HEV),

conventional

CDH5, PECAM1, NR2F2 ,CD34, EMCN, LTBR, ICAM1/2, VCAM1

Tumor associated HEV

  • SELP, SELE, CXCL9, CXCL10, VCAN, TNFRSF9
  • Exclusive: FUT7, GCNT1, CHST4, CCL21A

Melanocytes

PMEL

Fibroblast

COL1A1,COL1A2,MMP2,NT5E,EMILIN1,SFRP2

F1/3

TNFAIP6,IL6,CXCL1,MT2A,PTGES(F3:CD82,CCL19,TNS,TGFB3)

F2

CXCL3,CXCL12

Ganglia

SCG2,CHGB,STMN2

Myofibroblast

MYL9,acta2,pdgfrb

Macrophage

FCGR2A,C1QC

Mast

TPSAB1,CPA3,TPSB2,LIF

Kidney

Glomerulus(Podocytes)

WT1,PODXL,PTPRO

Proximal tubules()

SLC22A8,SLC17A3,SLC22A7,SLC16A9,SLC7A13,SLC34A1,SLC13A3

Distal tubules(Distal/Principal)

KCNJ1,SLC8A1,AVPR2,CLDN8,AQP2

Collecting duct(TypeA,TypeB)

CLCNKB,ATP6V0D2,SLC26A4,SLC4A1

Pelvic epithelium

SAA2,KRT23

Ureter(Basal + intermdiate)|(Superficial)

KRT5,PVRL4,TP63|S100P,DHRS2,UPK1A,UPK1B