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  • Download Gnomad 2.1.1
for i in {1..22} X Y
do
wget https://storage.googleapis.com/gnomad-public/release/2.1/vcf/genomes/gnomad.genomes.r2.1.sites.chr$i.vcf.bgz
wget https://storage.googleapis.com/gnomad-public/release/2.1/vcf/genomes/gnomad.genomes.r2.1.sites.chr$i.vcf.bgz.tbi
wget https://storage.googleapis.com/gnomad-public/release/2.1/vcf/exomes/gnomad.exomes.r2.1.sites.chr$i.vcf.bgz
wget https://storage.googleapis.com/gnomad-public/release/2.1/vcf/exomes/gnomad.exomes.r2.1.sites.chr$i.vcf.bgz.tbi
wget https://storage.googleapis.com/gnomad-public/release/3.0/vcf/genomes/gnomad.genomes.r3.0.sites.chr$i.vcf.bgz
wget https://storage.googleapis.com/gnomad-public/release/3.0/vcf/genomes/gnomad.genomes.r3.0.sites.chr$i.vcf.bgz.tbi
done
  • Add fake genotypes
  • vcf2plink