diff --git a/.DS_Store b/.DS_Store
new file mode 100644
index 00000000..d5cffbd0
Binary files /dev/null and b/.DS_Store differ
diff --git a/README.md b/README.md
index f5fe45ef..2340f38d 100644
--- a/README.md
+++ b/README.md
@@ -30,11 +30,19 @@ scGPT works with Python >= 3.7.13 and R >=3.6.1. Please make sure you have the c
 scGPT is available on PyPI. To install scGPT, run the following command:
 
 ```bash
-pip install scgpt "flash-attn<1.0.5"  # optional, recommended
+pip install scgpt ninja packaging && FLASH_ATTENTION_SKIP_CUDA_BUILD=TRUE pip install flash-attn --no-build-isolation  # optional, recommended
 # As of 2023.09, pip install may not run with new versions of the google orbax package, if you encounter related issues, please use the following command instead:
-# pip install scgpt "flash-attn<1.0.5" "orbax<0.1.8"
+# pip install scgpt ninja packaging "orbax<0.1.8" && FLASH_ATTENTION_SKIP_CUDA_BUILD=TRUE pip install flash-attn --no-build-isolation
 ```
 
+**Note**: 
+The `flash-attn` dependency requires `CUDA >= 11.6, PyTorch >= 1.12, Linux`.
+If you encounter any issues, please refer to the [flash-attn](https://github.com/HazyResearch/flash-attention/tree/main) repository for installation instructions. 
+For now, ~~May 2023, we recommend using CUDA 11.7 and flash-attn<1.0.5 due to various issues reported about installing new versions of flash-attn.~~
+we are using the latest flash-attn2, but please be aware that depends on the gpu architecture,
+Ampere, Ada, or Hopper GPUs (e.g., A100, RTX 3090, RTX 4090, H100) are tested and supported, however,
+Turing GPUs (T4, RTX 2080) are not supported in flash-attn2 but in flash-attn 1.x
+
 [Optional] We recommend using [wandb](https://wandb.ai/) for logging and visualization.
 
 ```bash
@@ -49,8 +57,6 @@ $ cd scGPT
 $ poetry install
 ```
 
-**Note**: The `flash-attn` dependency usually requires specific GPU and CUDA version. If you encounter any issues, please refer to the [flash-attn](https://github.com/HazyResearch/flash-attention/tree/main) repository for installation instructions. For now, May 2023, we recommend using CUDA 11.7 and flash-attn<1.0.5 due to various issues reported about installing new versions of flash-attn.
-
 ## Pretrained scGPT Model Zoo
 
 Here is the list of pretrained models. Please find the links for downloading the checkpoint folders. We recommend using the `whole-human` model for most applications by default. If your fine-tuning dataset shares similar cell type context with the training data of the organ-specific models, these models can usually demonstrate competitive performance as well. A paired vocabulary file mapping gene names to ids is provided in each checkpoint folder. If ENSEMBL ids are needed, please find the conversion at [gene_info.csv](https://github.com/bowang-lab/scGPT/files/13243634/gene_info.csv).
diff --git a/pyproject.toml b/pyproject.toml
index f402c050..b6471bba 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -29,7 +29,7 @@ orbax = "<0.1.8"
 pytest = "^5.2"
 black = "^22.3.0"
 tensorflow = "^2.8.0"
-flash-attn = "^1.0.1"
+flash-attn = ">=2.4.2"
 torch-geometric = "^2.3.0"
 dcor = "~0.5.3"
 wandb = "^0.12.3"
diff --git a/scgpt/model/model.py b/scgpt/model/model.py
index ad0639be..b3550d05 100644
--- a/scgpt/model/model.py
+++ b/scgpt/model/model.py
@@ -12,7 +12,7 @@
 from tqdm import trange
 
 try:
-    from flash_attn.flash_attention import FlashMHA
+    from flash_attn.modules.mha import MHA
 
     flash_attn_available = True
 except ImportError:
@@ -634,11 +634,11 @@ def __init__(
     ) -> None:
         factory_kwargs = {"device": device, "dtype": dtype}
         super().__init__()
-        self.self_attn = FlashMHA(
+        self.self_attn = MHA(
             embed_dim=d_model,
             num_heads=nhead,
-            batch_first=batch_first,
-            attention_dropout=dropout,
+            dropout=dropout,
+            use_flash_attn=False,
             **factory_kwargs,
         )
         # Version compatibility workaround
diff --git a/scgpt/model/multiomic_model.py b/scgpt/model/multiomic_model.py
index 5128fac7..aded0913 100644
--- a/scgpt/model/multiomic_model.py
+++ b/scgpt/model/multiomic_model.py
@@ -12,7 +12,7 @@
 from tqdm import trange
 
 try:
-    from flash_attn.flash_attention import FlashMHA
+    from flash_attn.modules.mha import MHA
 except ImportError:
     import warnings
 
@@ -668,11 +668,11 @@ def __init__(
     ) -> None:
         factory_kwargs = {"device": device, "dtype": dtype}
         super().__init__()
-        self.self_attn = FlashMHA(
+        self.self_attn = MHA(
             embed_dim=d_model,
             num_heads=nhead,
-            batch_first=batch_first,
-            attention_dropout=dropout,
+            dropout=dropout,
+            use_flash_attn=False,
             **factory_kwargs,
         )
         # Implementation of Feedforward model