Client:
 -- Firefox nightly with about:config network.http.spdy.enabled.http2draft set true
 -- Chrome: go to chrome://flags/#enable-spdy4, save and restart (button at bottom)

Make CA:
$ openssl genrsa -out rootCA.key 2048
$ openssl req -x509 -new -nodes -key rootCA.key -days 1024 -out rootCA.pem
... install that to Firefox

Make cert:
$ openssl genrsa -out server.key 2048
$ openssl req -new -key server.key -out server.csr
$ openssl x509 -req -in server.csr -CA rootCA.pem -CAkey rootCA.key -CAcreateserial -out server.crt -days 500