diff --git a/chrome/browser/translate/translate_manager_browsertest.cc b/chrome/browser/translate/translate_manager_browsertest.cc
index b5aae4b261dba2..532a502f693445 100644
--- a/chrome/browser/translate/translate_manager_browsertest.cc
+++ b/chrome/browser/translate/translate_manager_browsertest.cc
@@ -407,6 +407,41 @@ IN_PROC_BROWSER_TEST_F(TranslateManagerBrowserTest, PageTranslationSuccess) {
   EXPECT_EQ(translate::TranslateErrors::NONE, GetPageTranslatedResult());
 }
 
+// Test that the translation was successful in an about:blank page.
+// This is a regression test for https://crbug.com/943685.
+IN_PROC_BROWSER_TEST_F(TranslateManagerBrowserTest, PageTranslationAboutBlank) {
+  SetTranslateScript(kTestValidScript);
+  ResetObserver();
+  AddTabAtIndex(0, GURL(embedded_test_server()->GetURL("/french_page.html")),
+                ui::PAGE_TRANSITION_TYPED);
+
+  // Open a pop-up window and leave it at the initial about:blank URL.
+  content::WebContentsAddedObserver popup_observer;
+  ASSERT_TRUE(
+      content::ExecJs(browser()->tab_strip_model()->GetActiveWebContents(),
+                      "window.open('about:blank', 'popup')"));
+  content::WebContents* popup = popup_observer.GetWebContents();
+
+  // A round-trip to the renderer process helps avoid a race where the
+  // browser-side translate structures are not yet ready for the translate call.
+  EXPECT_EQ("ping", content::EvalJs(popup, "'ping'"));
+
+  // Translate the about:blank page.
+  ChromeTranslateClient* chrome_translate_client =
+      ChromeTranslateClient::FromWebContents(popup);
+  translate::TranslateManager* manager =
+      chrome_translate_client->GetTranslateManager();
+  manager->TranslatePage("fr", "en", true);
+
+  // Verify that the crash from https://crbug.com/943685 didn't happen.
+  EXPECT_EQ("still alive", content::EvalJs(popup, "'still alive'"));
+
+  // Wait for translation to finish and verify it was successful.
+  WaitUntilPageTranslated();
+  EXPECT_FALSE(chrome_translate_client->GetLanguageState().translation_error());
+  EXPECT_EQ(translate::TranslateErrors::NONE, GetPageTranslatedResult());
+}
+
 // Test that hrefTranslate is propagating properly
 IN_PROC_BROWSER_TEST_F(TranslateManagerBrowserTest, HrefTranslateSuccess) {
   ChromeTranslateClient* chrome_translate_client = GetChromeTranslateClient();
diff --git a/content/renderer/render_frame_impl.cc b/content/renderer/render_frame_impl.cc
index 9c4b0d72ff2e16..73032592f5d4c7 100644
--- a/content/renderer/render_frame_impl.cc
+++ b/content/renderer/render_frame_impl.cc
@@ -3847,10 +3847,28 @@ void RenderFrameImpl::UpdateSubresourceLoaderFactories(
     std::unique_ptr<blink::URLLoaderFactoryBundleInfo>
         subresource_loader_factories) {
   DCHECK(loader_factories_);
-  // TODO(crbug/916625): CHECKing for crbug.com/916625.
-  CHECK(loader_factories_->IsHostChildURLLoaderFactoryBundle());
-  static_cast<HostChildURLLoaderFactoryBundle*>(loader_factories_.get())
-      ->UpdateThisAndAllClones(std::move(subresource_loader_factories));
+  if (loader_factories_->IsHostChildURLLoaderFactoryBundle()) {
+    static_cast<HostChildURLLoaderFactoryBundle*>(loader_factories_.get())
+        ->UpdateThisAndAllClones(std::move(subresource_loader_factories));
+  } else {
+#if DCHECK_IS_ON()
+    // In presence of the NetworkService, this situation should happen only if
+    // the frame hosts a document that isn't related to a real navigation (i.e.
+    // if the frame should "inherit" the factories from its opener/parent - for
+    // example for about:blank or about:srcdoc or about:blank#someHref frames,
+    // or for frames with no URL - like the initial frame opened by window('',
+    // 'popup')).
+    if (base::FeatureList::IsEnabled(network::features::kNetworkService)) {
+      WebURL url = GetWebFrame()->GetDocument().Url();
+      if (url.IsValid() && !url.IsEmpty())
+        DCHECK(url.ProtocolIs(url::kAboutScheme));
+    }
+#endif
+    auto partial_bundle = base::MakeRefCounted<ChildURLLoaderFactoryBundle>();
+    static_cast<blink::URLLoaderFactoryBundle*>(partial_bundle.get())
+        ->Update(std::move(subresource_loader_factories));
+    loader_factories_->Update(partial_bundle->PassInterface());
+  }
 }
 
 void RenderFrameImpl::MarkInitiatorAsRequiringSeparateURLLoaderFactory(