simglucose

A Type-1 Diabetes simulator implemented in Python for Reinforcement Learning purpose

This simulator is a python implementation of the FDA-approved UVa/Padova Simulator (2008 version) for research purpose only. The simulator includes 30 virtual patients, 10 adolescents, 10 adults, 10 children.

• Note: simglucose only supports python3.

Animation	CVGA Plot	BG Trace Plot	Risk Index Stats

Main Features

• Simulation enviroment follows OpenAI gym and rllab APIs. It returns observation, reward, done, info at each step, which means the simulator is "reinforcement-learning-ready".
• Supports customized reward function. The reward function is a function of blood glucose measurements in the last hour. By default, the reward at each step is risk[t-1] - risk[t]. risk[t] is the risk index at time t defined in this paper.
• Supports parallel computing. The simulator simulates mutliple patients parallelly using pathos multiprocessing package (you are free to turn parallel off by setting parallel=False).
• The simulator provides a random scenario generator (from simglucose.simulation.scenario_gen import RandomScenario) and a customized scenario generator (from simglucose.simulation.scenario import CustomScnenario). Commandline user-interface will guide you through the scenario settings.
• The simulator provides the most basic basal-bolus controller for now. It provides very simple syntax to implement your own controller, like Model Predictive Control, PID control, reinforcement learning control, etc.
• You can specify random seed in case you want to repeat your experiments.
• The simulator will generate several plots for performance analysis after simulation. The plots include blood glucose trace plot, Control Variability Grid Analysis (CVGA) plot, statistics plot of blood glucose in different zones, risk indices statistics plot.
• NOTE: animate and parallel cannot be set to True at the same time in macOS. Most backends of matplotlib in macOS is not thread-safe. Windows has not been tested. Let me know the results if anybody has tested it out.

Installation

It is highly recommended to use pip to install simglucose, follow this link to install pip.

Auto installation:

pip install simglucose

Manual installation:

git clone https://github.com/jxx123/simglucose.git
cd simglucose

If you have pip installed, then

pip install -e .

If you do not have pip, then

python setup.py install

If rllab (optional) is installed, the package will utilize some functionalities in rllab.

Note: there might be some minor differences between auto install version and manual install version. Use git clone and manual installation to get the latest version.

Quick Start

Use simglucose as a simulator and test controllers

Run the simulator user interface

from simglucose.simulation.user_interface import simulate
simulate()

You are free to implement your own controller, and test it in the simulator. For example,

from simglucose.simulation.user_interface import simulate
from simglucose.controller.base import Controller, Action


class MyController(Controller):
    def __init__(self, init_state):
        self.init_state = init_state
        self.state = init_state

    def policy(self, observation, reward, done, **info):
        '''
        Every controller must have this implementation!
        ----
        Inputs:
        observation - a namedtuple defined in simglucose.simulation.env. For
                      now, it only has one entry: blood glucose level measured
                      by CGM sensor.
        reward      - current reward returned by environment
        done        - True, game over. False, game continues
        info        - additional information as key word arguments,
                      simglucose.simulation.env.T1DSimEnv returns patient_name
                      and sample_time
        ----
        Output:
        action - a namedtuple defined at the beginning of this file. The
                 controller action contains two entries: basal, bolus
        '''
        self.state = observation
        action = Action(basal=0, bolus=0)
        return action

    def reset(self):
        '''
        Reset the controller state to inital state, must be implemented
        '''
        self.state = self.init_state


ctrller = MyController(0)
simulate(controller=ctrller)

These two examples can also be found in examples\ folder.

In fact, you can specify a lot more simulation parameters through simulation:

simulate(sim_time=my_sim_time,
         scenario=my_scenario,
         controller=my_controller,
         start_time=my_start_time,
         save_path=my_save_path,
         animate=False,
         parallel=True)

OpenAI Gym usage

• Using default reward

import gym

# Register gym environment. By specifying kwargs,
# you are able to choose which patient to simulate.
# patient_name must be 'adolescent#001' to 'adolescent#010',
# or 'adult#001' to 'adult#010', or 'child#001' to 'child#010'
from gym.envs.registration import register
register(
    id='simglucose-adolescent2-v0',
    entry_point='simglucose.envs:T1DSimEnv',
    kwargs={'patient_name': 'adolescent#002'}
)

env = gym.make('simglucose-adolescent2-v0')

observation = env.reset()
for t in range(100):
    env.render(mode='human')
    print(observation)
    # Action in the gym environment is a scalar
    # representing the basal insulin, which differs from
    # the regular controller action outside the gym
    # environment (a tuple (basal, bolus)).
    # In the perfect situation, the agent should be able
    # to control the glucose only through basal instead
    # of asking patient to take bolus
    action = env.action_space.sample()
    observation, reward, done, info = env.step(action)
    if done:
        print("Episode finished after {} timesteps".format(t + 1))
        break

• Customized reward function

import gym
from gym.envs.registration import register


def custom_reward(BG_last_hour):
    if BG_last_hour[-1] > 180:
        return -1
    elif BG_last_hour[-1] < 70:
        return -2
    else:
        return 1


register(
    id='simglucose-adolescent2-v0',
    entry_point='simglucose.envs:T1DSimEnv',
    kwargs={'patient_name': 'adolescent#002',
            'reward_fun': custom_reward}
)

env = gym.make('simglucose-adolescent2-v0')

reward = 1
done = False

observation = env.reset()
for t in range(200):
    env.render(mode='human')
    action = env.action_space.sample()
    observation, reward, done, info = env.step(action)
    print(observation)
    print("Reward = {}".format(reward))
    if done:
        print("Episode finished after {} timesteps".format(t + 1))
        break

rllab usage

from rllab.algos.ddpg import DDPG
from rllab.envs.normalized_env import normalize
from rllab.exploration_strategies.ou_strategy import OUStrategy
from rllab.policies.deterministic_mlp_policy import DeterministicMLPPolicy
from rllab.q_functions.continuous_mlp_q_function import ContinuousMLPQFunction
from rllab.envs.gym_env import GymEnv
from gym.envs.registration import register

register(
    id='simglucose-adolescent2-v0',
    entry_point='simglucose.envs:T1DSimEnv',
    kwargs={'patient_name': 'adolescent#002'}
)

env = GymEnv('simglucose-adolescent2-v0')
env = normalize(env)

policy = DeterministicMLPPolicy(
    env_spec=env.spec,
    # The neural network policy should have two hidden layers, each with 32 hidden units.
    hidden_sizes=(32, 32)
)

es = OUStrategy(env_spec=env.spec)

qf = ContinuousMLPQFunction(env_spec=env.spec)

algo = DDPG(
    env=env,
    policy=policy,
    es=es,
    qf=qf,
    batch_size=32,
    max_path_length=100,
    epoch_length=1000,
    min_pool_size=10000,
    n_epochs=1000,
    discount=0.99,
    scale_reward=0.01,
    qf_learning_rate=1e-3,
    policy_learning_rate=1e-4
)
algo.train()

Advanced Usage

You can create the simulation objects, and run batch simulation. For example,

from simglucose.simulation.env import T1DSimEnv
from simglucose.controller.basal_bolus_ctrller import BBController
from simglucose.sensor.cgm import CGMSensor
from simglucose.actuator.pump import InsulinPump
from simglucose.patient.t1dpatient import T1DPatient
from simglucose.simulation.scenario_gen import RandomScenario
from simglucose.simulation.scenario import CustomScenario
from simglucose.simulation.sim_engine import SimObj, sim, batch_sim
from datetime import timedelta
from datetime import datetime

# specify start_time as the beginning of today
now = datetime.now()
start_time = datetime.combine(now.date(), datetime.min.time())

# --------- Create Random Scenario --------------
# Specify results saving path
path = './results'

# Create a simulation environment
patient = T1DPatient.withName('adolescent#001')
sensor = CGMSensor.withName('Dexcom', seed=1)
pump = InsulinPump.withName('Insulet')
scenario = RandomScenario(start_time=start_time, seed=1)
env = T1DSimEnv(patient, sensor, pump, scenario)

# Create a controller
controller = BBController()

# Put them together to create a simulation object
s1 = SimObj(env, controller, timedelta(days=1), animate=False, path=path)
results1 = sim(s1)
print(results1)

# --------- Create Custom Scenario --------------
# Create a simulation environment
patient = T1DPatient.withName('adolescent#001')
sensor = CGMSensor.withName('Dexcom', seed=1)
pump = InsulinPump.withName('Insulet')
# custom scenario is a list of tuples (time, meal_size)
scen = [(7, 45), (12, 70), (16, 15), (18, 80), (23, 10)]
scenario = CustomScenario(start_time=start_time, scenario=scen)
env = T1DSimEnv(patient, sensor, pump, scenario)

# Create a controller
controller = BBController()

# Put them together to create a simulation object
s2 = SimObj(env, controller, timedelta(days=1), animate=False, path=path)
results2 = sim(s2)
print(results2)


# --------- batch simulation --------------
# Re-initialize simulation objects
s1.reset()
s2.reset()

# create a list of SimObj, and call batch_sim
s = [s1, s2]
results = batch_sim(s, parallel=True)
print(results)

Run analysis offline

from simglucose.analysis.report import report
import pandas as pd
import os
import glob

# the path where results are saved
path = os.path.join('.', 'results', '2017-12-31_17-46-32')
os.chdir(path)
# find all csv with pattern *#*.csv, e.g. adolescent#001.csv
filename = glob.glob('*#*.csv')
name = [_f[:-4] for _f in filename]   # get the filename without extension
df = pd.concat([pd.read_csv(f, index_col=0) for f in filename], keys=name)
report(df)

Release Notes, 2/26/2017

• Support customized reward function.

Release Notes, 1/10/2017

• Added workaround to select patient when make gym environment: register gym environment by passing kwargs of patient_name.

Release Notes, 1/7/2017

• Added OpenAI gym support, use gym.make('simglucose-v0') to make the enviroment.
• Noticed issue: the patient name selection is not available in gym.make for now. The patient name has to be hard-coded in the constructor of simglucose.envs.T1DSimEnv.