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2src.pdb
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2src.pdb
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HEADER TYROSINE-PROTEIN KINASE 29-DEC-98 2SRC
TITLE CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC,
TITLE 2 IN COMPLEX WITH AMP-PNP
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: TYROSINE-PROTEIN KINASE SRC;
COMPND 3 CHAIN: A;
COMPND 4 FRAGMENT: RESIDUES 86-836, CONTAINING SH2, SH3, KINASE 2
COMPND 5 DOMAINS AND C-TERMINAL TAIL;
COMPND 6 SYNONYM: C-SRC, P60-SRC;
COMPND 7 EC: 2.7.1.112;
COMPND 8 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 3 ORGANISM_COMMON: HUMAN;
SOURCE 4 ORGANISM_TAXID: 9606;
SOURCE 5 EXPRESSION_SYSTEM: SPODOPTERA FRUGIPERDA;
SOURCE 6 EXPRESSION_SYSTEM_COMMON: FALL ARMYWORM;
SOURCE 7 EXPRESSION_SYSTEM_TAXID: 7108;
SOURCE 8 EXPRESSION_SYSTEM_VECTOR: BACULOVIRUS
KEYWDS SRC, TYROSINE-PROTEIN KINASE, PHOSPHORYLATION, SH2, SH3,
KEYWDS 2 PHOSPHOTYROSINE, PROTO-ONCOGENE, PHOSPHOTRANSFERASE
EXPDTA X-RAY DIFFRACTION
AUTHOR W.XU,A.DOSHI,M.LEI,M.J.ECK,S.C.HARRISON
REVDAT 3 24-FEB-09 2SRC 1 VERSN
REVDAT 2 01-APR-03 2SRC 1 JRNL
REVDAT 1 22-JUL-99 2SRC 0
JRNL AUTH W.XU,A.DOSHI,M.LEI,M.J.ECK,S.C.HARRISON
JRNL TITL CRYSTAL STRUCTURES OF C-SRC REVEAL FEATURES OF ITS
JRNL TITL 2 AUTOINHIBITORY MECHANISM.
JRNL REF MOL.CELL V. 3 629 1999
JRNL REFN ISSN 1097-2765
JRNL PMID 10360179
JRNL DOI 10.1016/S1097-2765(00)80356-1
REMARK 1
REMARK 2
REMARK 2 RESOLUTION. 1.50 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 PROGRAM : X-PLOR
REMARK 3 AUTHORS : BRUNGER
REMARK 3
REMARK 3 DATA USED IN REFINEMENT.
REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 1.50
REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 20.00
REMARK 3 DATA CUTOFF (SIGMA(F)) : 2.000
REMARK 3 DATA CUTOFF HIGH (ABS(F)) : NULL
REMARK 3 DATA CUTOFF LOW (ABS(F)) : NULL
REMARK 3 COMPLETENESS (WORKING+TEST) (%) : 89.1
REMARK 3 NUMBER OF REFLECTIONS : 296913
REMARK 3
REMARK 3 FIT TO DATA USED IN REFINEMENT.
REMARK 3 CROSS-VALIDATION METHOD : NULL
REMARK 3 FREE R VALUE TEST SET SELECTION : NULL
REMARK 3 R VALUE (WORKING SET) : 0.226
REMARK 3 FREE R VALUE : 0.281
REMARK 3 FREE R VALUE TEST SET SIZE (%) : 5.000
REMARK 3 FREE R VALUE TEST SET COUNT : 2560
REMARK 3 ESTIMATED ERROR OF FREE R VALUE : NULL
REMARK 3
REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN.
REMARK 3 TOTAL NUMBER OF BINS USED : NULL
REMARK 3 BIN RESOLUTION RANGE HIGH (A) : NULL
REMARK 3 BIN RESOLUTION RANGE LOW (A) : NULL
REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) : NULL
REMARK 3 REFLECTIONS IN BIN (WORKING SET) : NULL
REMARK 3 BIN R VALUE (WORKING SET) : NULL
REMARK 3 BIN FREE R VALUE : NULL
REMARK 3 BIN FREE R VALUE TEST SET SIZE (%) : NULL
REMARK 3 BIN FREE R VALUE TEST SET COUNT : NULL
REMARK 3 ESTIMATED ERROR OF BIN FREE R VALUE : NULL
REMARK 3
REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK 3 PROTEIN ATOMS : 3615
REMARK 3 NUCLEIC ACID ATOMS : 0
REMARK 3 HETEROGEN ATOMS : 0
REMARK 3 SOLVENT ATOMS : 269
REMARK 3
REMARK 3 B VALUES.
REMARK 3 FROM WILSON PLOT (A**2) : NULL
REMARK 3 MEAN B VALUE (OVERALL, A**2) : 31.20
REMARK 3 OVERALL ANISOTROPIC B VALUE.
REMARK 3 B11 (A**2) : NULL
REMARK 3 B22 (A**2) : NULL
REMARK 3 B33 (A**2) : NULL
REMARK 3 B12 (A**2) : NULL
REMARK 3 B13 (A**2) : NULL
REMARK 3 B23 (A**2) : NULL
REMARK 3
REMARK 3 ESTIMATED COORDINATE ERROR.
REMARK 3 ESD FROM LUZZATI PLOT (A) : NULL
REMARK 3 ESD FROM SIGMAA (A) : NULL
REMARK 3 LOW RESOLUTION CUTOFF (A) : NULL
REMARK 3
REMARK 3 CROSS-VALIDATED ESTIMATED COORDINATE ERROR.
REMARK 3 ESD FROM C-V LUZZATI PLOT (A) : NULL
REMARK 3 ESD FROM C-V SIGMAA (A) : NULL
REMARK 3
REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES.
REMARK 3 BOND LENGTHS (A) : 0.007
REMARK 3 BOND ANGLES (DEGREES) : 1.27
REMARK 3 DIHEDRAL ANGLES (DEGREES) : NULL
REMARK 3 IMPROPER ANGLES (DEGREES) : NULL
REMARK 3
REMARK 3 ISOTROPIC THERMAL MODEL : NULL
REMARK 3
REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. RMS SIGMA
REMARK 3 MAIN-CHAIN BOND (A**2) : NULL ; NULL
REMARK 3 MAIN-CHAIN ANGLE (A**2) : NULL ; NULL
REMARK 3 SIDE-CHAIN BOND (A**2) : NULL ; NULL
REMARK 3 SIDE-CHAIN ANGLE (A**2) : NULL ; NULL
REMARK 3
REMARK 3 NCS MODEL : NULL
REMARK 3
REMARK 3 NCS RESTRAINTS. RMS SIGMA/WEIGHT
REMARK 3 GROUP 1 POSITIONAL (A) : NULL ; NULL
REMARK 3 GROUP 1 B-FACTOR (A**2) : NULL ; NULL
REMARK 3
REMARK 3 PARAMETER FILE 1 : NULL
REMARK 3 TOPOLOGY FILE 1 : NULL
REMARK 3
REMARK 3 OTHER REFINEMENT REMARKS: NULL
REMARK 4
REMARK 4 2SRC COMPLIES WITH FORMAT V. 3.15, 01-DEC-08
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY BNL.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION
REMARK 200 DATE OF DATA COLLECTION : NULL
REMARK 200 TEMPERATURE (KELVIN) : 100
REMARK 200 PH : 6.5
REMARK 200 NUMBER OF CRYSTALS USED : NULL
REMARK 200
REMARK 200 SYNCHROTRON (Y/N) : Y
REMARK 200 RADIATION SOURCE : CHESS
REMARK 200 BEAMLINE : F1
REMARK 200 X-RAY GENERATOR MODEL : NULL
REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M
REMARK 200 WAVELENGTH OR RANGE (A) : 0.900
REMARK 200 MONOCHROMATOR : NULL
REMARK 200 OPTICS : NULL
REMARK 200
REMARK 200 DETECTOR TYPE : NULL
REMARK 200 DETECTOR MANUFACTURER : NULL
REMARK 200 INTENSITY-INTEGRATION SOFTWARE : NULL
REMARK 200 DATA SCALING SOFTWARE : NULL
REMARK 200
REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 55186
REMARK 200 RESOLUTION RANGE HIGH (A) : 1.800
REMARK 200 RESOLUTION RANGE LOW (A) : 20.000
REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200 COMPLETENESS FOR RANGE (%) : 93.2
REMARK 200 DATA REDUNDANCY : 5.400
REMARK 200 R MERGE (I) : NULL
REMARK 200 R SYM (I) : 0.05100
REMARK 200 <I/SIGMA(I)> FOR THE DATA SET : NULL
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL
REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : NULL
REMARK 200 COMPLETENESS FOR SHELL (%) : NULL
REMARK 200 DATA REDUNDANCY IN SHELL : NULL
REMARK 200 R MERGE FOR SHELL (I) : NULL
REMARK 200 R SYM FOR SHELL (I) : NULL
REMARK 200 <I/SIGMA(I)> FOR SHELL : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: NULL
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: X-PLOR
REMARK 200 STARTING MODEL: PDB ENTRY 1FMK
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS (%): 60.07
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.08
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: PH 6.5
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21
REMARK 290
REMARK 290 SYMOP SYMMETRY
REMARK 290 NNNMMM OPERATOR
REMARK 290 1555 X,Y,Z
REMARK 290 2555 -X+1/2,-Y,Z+1/2
REMARK 290 3555 -X,Y+1/2,-Z+1/2
REMARK 290 4555 X+1/2,-Y+1/2,-Z
REMARK 290
REMARK 290 WHERE NNN -> OPERATOR NUMBER
REMARK 290 MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000
REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000
REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000
REMARK 290 SMTRY1 2 -1.000000 0.000000 0.000000 25.29500
REMARK 290 SMTRY2 2 0.000000 -1.000000 0.000000 0.00000
REMARK 290 SMTRY3 2 0.000000 0.000000 1.000000 86.34500
REMARK 290 SMTRY1 3 -1.000000 0.000000 0.000000 0.00000
REMARK 290 SMTRY2 3 0.000000 1.000000 0.000000 36.48500
REMARK 290 SMTRY3 3 0.000000 0.000000 -1.000000 86.34500
REMARK 290 SMTRY1 4 1.000000 0.000000 0.000000 25.29500
REMARK 290 SMTRY2 4 0.000000 -1.000000 0.000000 36.48500
REMARK 290 SMTRY3 4 0.000000 0.000000 -1.000000 0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: MONOMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A 82
REMARK 465 VAL A 83
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS(M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470 M RES CSSEQI ATOMS
REMARK 470 LYS A 423 CG CD CE NZ
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 O HOH A 1043 O HOH A 1157 2.08
REMARK 500 O HOH A 1011 O HOH A 1225 2.14
REMARK 500 O HOH A 1147 O HOH A 1200 2.16
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 ASN A 112 112.88 175.15
REMARK 500 THR A 114 11.13 -65.18
REMARK 500 GLU A 115 -154.97 -107.22
REMARK 500 LYS A 195 -14.88 -178.70
REMARK 500 LEU A 207 176.57 -52.55
REMARK 500 ASP A 235 61.25 37.28
REMARK 500 TRP A 260 -74.67 -151.30
REMARK 500 THR A 289 -35.71 -134.22
REMARK 500 ARG A 385 -7.89 81.61
REMARK 500 ASP A 386 47.27 -152.97
REMARK 500 GLU A 486 -9.59 77.50
REMARK 500 THR A 521 88.15 18.66
REMARK 500 SER A 522 72.16 -178.55
REMARK 500 THR A 523 26.06 -70.87
REMARK 500 PRO A 525 -157.40 -105.42
REMARK 500
REMARK 500 REMARK: NULL
REMARK 525
REMARK 525 SOLVENT
REMARK 525
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE
REMARK 525 NUMBER; I=INSERTION CODE):
REMARK 525
REMARK 525 M RES CSSEQI
REMARK 525 HOH A1244 DISTANCE = 5.41 ANGSTROMS
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ANP A 1
DBREF 2SRC A 83 533 UNP P12931 SRC_HUMAN 85 535
SEQADV 2SRC PTR A 527 UNP P12931 TYR 529 MODIFIED RESIDUE
SEQRES 1 A 452 MET VAL THR THR PHE VAL ALA LEU TYR ASP TYR GLU SER
SEQRES 2 A 452 ARG THR GLU THR ASP LEU SER PHE LYS LYS GLY GLU ARG
SEQRES 3 A 452 LEU GLN ILE VAL ASN ASN THR GLU GLY ASP TRP TRP LEU
SEQRES 4 A 452 ALA HIS SER LEU SER THR GLY GLN THR GLY TYR ILE PRO
SEQRES 5 A 452 SER ASN TYR VAL ALA PRO SER ASP SER ILE GLN ALA GLU
SEQRES 6 A 452 GLU TRP TYR PHE GLY LYS ILE THR ARG ARG GLU SER GLU
SEQRES 7 A 452 ARG LEU LEU LEU ASN ALA GLU ASN PRO ARG GLY THR PHE
SEQRES 8 A 452 LEU VAL ARG GLU SER GLU THR THR LYS GLY ALA TYR CYS
SEQRES 9 A 452 LEU SER VAL SER ASP PHE ASP ASN ALA LYS GLY LEU ASN
SEQRES 10 A 452 VAL LYS HIS TYR LYS ILE ARG LYS LEU ASP SER GLY GLY
SEQRES 11 A 452 PHE TYR ILE THR SER ARG THR GLN PHE ASN SER LEU GLN
SEQRES 12 A 452 GLN LEU VAL ALA TYR TYR SER LYS HIS ALA ASP GLY LEU
SEQRES 13 A 452 CYS HIS ARG LEU THR THR VAL CYS PRO THR SER LYS PRO
SEQRES 14 A 452 GLN THR GLN GLY LEU ALA LYS ASP ALA TRP GLU ILE PRO
SEQRES 15 A 452 ARG GLU SER LEU ARG LEU GLU VAL LYS LEU GLY GLN GLY
SEQRES 16 A 452 CYS PHE GLY GLU VAL TRP MET GLY THR TRP ASN GLY THR
SEQRES 17 A 452 THR ARG VAL ALA ILE LYS THR LEU LYS PRO GLY THR MET
SEQRES 18 A 452 SER PRO GLU ALA PHE LEU GLN GLU ALA GLN VAL MET LYS
SEQRES 19 A 452 LYS LEU ARG HIS GLU LYS LEU VAL GLN LEU TYR ALA VAL
SEQRES 20 A 452 VAL SER GLU GLU PRO ILE TYR ILE VAL THR GLU TYR MET
SEQRES 21 A 452 SER LYS GLY SER LEU LEU ASP PHE LEU LYS GLY GLU THR
SEQRES 22 A 452 GLY LYS TYR LEU ARG LEU PRO GLN LEU VAL ASP MET ALA
SEQRES 23 A 452 ALA GLN ILE ALA SER GLY MET ALA TYR VAL GLU ARG MET
SEQRES 24 A 452 ASN TYR VAL HIS ARG ASP LEU ARG ALA ALA ASN ILE LEU
SEQRES 25 A 452 VAL GLY GLU ASN LEU VAL CYS LYS VAL ALA ASP PHE GLY
SEQRES 26 A 452 LEU ALA ARG LEU ILE GLU ASP ASN GLU TYR THR ALA ARG
SEQRES 27 A 452 GLN GLY ALA LYS PHE PRO ILE LYS TRP THR ALA PRO GLU
SEQRES 28 A 452 ALA ALA LEU TYR GLY ARG PHE THR ILE LYS SER ASP VAL
SEQRES 29 A 452 TRP SER PHE GLY ILE LEU LEU THR GLU LEU THR THR LYS
SEQRES 30 A 452 GLY ARG VAL PRO TYR PRO GLY MET VAL ASN ARG GLU VAL
SEQRES 31 A 452 LEU ASP GLN VAL GLU ARG GLY TYR ARG MET PRO CYS PRO
SEQRES 32 A 452 PRO GLU CYS PRO GLU SER LEU HIS ASP LEU MET CYS GLN
SEQRES 33 A 452 CYS TRP ARG LYS GLU PRO GLU GLU ARG PRO THR PHE GLU
SEQRES 34 A 452 TYR LEU GLN ALA PHE LEU GLU ASP TYR PHE THR SER THR
SEQRES 35 A 452 GLU PRO GLN PTR GLN PRO GLY GLU ASN LEU
MODRES 2SRC PTR A 527 TYR O-PHOSPHOTYROSINE
HET PTR A 527 16
HET ANP A 1 31
HETNAM PTR O-PHOSPHOTYROSINE
HETNAM ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
HETSYN PTR PHOSPHONOTYROSINE
FORMUL 1 PTR C9 H12 N O6 P
FORMUL 2 ANP C10 H17 N6 O12 P3
FORMUL 3 HOH *269(H2 O)
HELIX 1 1 SER A 134 TYR A 136 5 3
HELIX 2 2 ARG A 155 LEU A 162 1 8
HELIX 3 3 LEU A 223 TYR A 229 1 7
HELIX 4 4 ARG A 264 SER A 266 5 3
HELIX 5 5 PRO A 304 LYS A 316 1 13
HELIX 6 6 LEU A 346 LEU A 350 1 5
HELIX 7 7 LEU A 360 ARG A 379 1 20
HELIX 8 8 ALA A 389 ASN A 391 5 3
HELIX 9 9 LEU A 407 LEU A 410 5 4
HELIX 10 10 ASN A 414 ALA A 418 1 5
HELIX 11 11 ILE A 426 TRP A 428 5 3
HELIX 12 12 PRO A 431 TYR A 436 1 6
HELIX 13 13 ILE A 441 LEU A 455 1 15
HELIX 14 14 ASN A 468 GLU A 476 1 9
HELIX 15 15 GLU A 489 CYS A 498 1 10
HELIX 16 16 PRO A 503 GLU A 505 5 3
HELIX 17 17 PHE A 509 GLU A 517 1 9
SHEET 1 A 2 PHE A 86 ALA A 88 0
SHEET 2 A 2 VAL A 137 PRO A 139 -1 N ALA A 138 O VAL A 87
SHEET 1 B 3 THR A 129 PRO A 133 0
SHEET 2 B 3 TRP A 118 SER A 123 -1 N ALA A 121 O GLY A 130
SHEET 3 B 3 LEU A 108 ASN A 112 -1 N ASN A 112 O LEU A 120
SHEET 1 C 3 PHE A 172 GLU A 176 0
SHEET 2 C 3 TYR A 184 ASP A 192 -1 N SER A 187 O LEU A 173
SHEET 3 C 3 GLY A 196 ILE A 204 -1 N ILE A 204 O TYR A 184
SHEET 1 D 5 LEU A 325 VAL A 329 0
SHEET 2 D 5 TYR A 335 THR A 338 -1 N VAL A 337 O TYR A 326
SHEET 3 D 5 THR A 290 LEU A 297 -1 N LYS A 295 O ILE A 336
SHEET 4 D 5 GLY A 279 TRP A 286 -1 N TRP A 286 O THR A 290
SHEET 5 D 5 LEU A 267 LYS A 272 -1 N VAL A 271 O MET A 283
SHEET 1 E 2 ILE A 392 GLY A 395 0
SHEET 2 E 2 VAL A 399 VAL A 402 -1 N LYS A 401 O LEU A 393
LINK N PTR A 527 C GLN A 526 1555 1555 1.33
LINK C PTR A 527 N GLN A 528 1555 1555 1.33
CISPEP 1 GLU A 332 PRO A 333 0 -0.29
SITE 1 AC1 20 LEU A 273 GLY A 276 VAL A 281 ALA A 293
SITE 2 AC1 20 LYS A 295 THR A 338 GLU A 339 TYR A 340
SITE 3 AC1 20 MET A 341 SER A 345 ASP A 386 ARG A 388
SITE 4 AC1 20 ASN A 391 LEU A 393 ASP A 404 HOH A1064
SITE 5 AC1 20 HOH A1147 HOH A1200 HOH A1208 HOH A1230
CRYST1 50.590 72.970 172.690 90.00 90.00 90.00 P 21 21 21 4
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 0.019767 0.000000 0.000000 0.00000
SCALE2 0.000000 0.013704 0.000000 0.00000
SCALE3 0.000000 0.000000 0.005791 0.00000
ATOM 1 N THR A 84 33.954 62.803 55.198 1.00 38.76 N
ATOM 2 CA THR A 84 32.735 62.188 54.583 1.00 39.76 C
ATOM 3 C THR A 84 32.941 60.717 54.186 1.00 37.91 C
ATOM 4 O THR A 84 32.021 60.068 53.678 1.00 36.13 O
ATOM 5 CB THR A 84 32.285 62.973 53.319 1.00 41.34 C
ATOM 6 OG1 THR A 84 33.424 63.240 52.489 1.00 41.84 O
ATOM 7 CG2 THR A 84 31.616 64.288 53.711 1.00 40.28 C
ATOM 8 N THR A 85 34.140 60.192 54.419 1.00 35.88 N
ATOM 9 CA THR A 85 34.437 58.806 54.075 1.00 34.00 C
ATOM 10 C THR A 85 34.001 57.804 55.154 1.00 33.76 C
ATOM 11 O THR A 85 33.807 58.168 56.320 1.00 30.78 O
ATOM 12 CB THR A 85 35.944 58.610 53.814 1.00 36.09 C
ATOM 13 OG1 THR A 85 36.671 58.783 55.036 1.00 39.72 O
ATOM 14 CG2 THR A 85 36.445 59.611 52.790 1.00 37.48 C
ATOM 15 N PHE A 86 33.832 56.547 54.746 1.00 28.75 N
ATOM 16 CA PHE A 86 33.449 55.480 55.665 1.00 25.99 C
ATOM 17 C PHE A 86 34.625 54.522 55.755 1.00 24.12 C
ATOM 18 O PHE A 86 35.606 54.655 55.013 1.00 23.08 O
ATOM 19 CB PHE A 86 32.223 54.724 55.157 1.00 24.62 C
ATOM 20 CG PHE A 86 30.915 55.310 55.598 1.00 23.17 C
ATOM 21 CD1 PHE A 86 30.463 56.515 55.066 1.00 26.21 C
ATOM 22 CD2 PHE A 86 30.108 54.636 56.508 1.00 25.23 C
ATOM 23 CE1 PHE A 86 29.218 57.039 55.432 1.00 24.64 C
ATOM 24 CE2 PHE A 86 28.858 55.150 56.885 1.00 26.97 C
ATOM 25 CZ PHE A 86 28.414 56.352 56.342 1.00 28.54 C
ATOM 26 N VAL A 87 34.533 53.566 56.672 1.00 23.62 N
ATOM 27 CA VAL A 87 35.593 52.580 56.854 1.00 23.37 C
ATOM 28 C VAL A 87 34.983 51.188 57.020 1.00 21.41 C
ATOM 29 O VAL A 87 33.925 51.029 57.632 1.00 19.70 O
ATOM 30 CB VAL A 87 36.471 52.926 58.087 1.00 25.01 C
ATOM 31 CG1 VAL A 87 35.672 52.736 59.377 1.00 25.81 C
ATOM 32 CG2 VAL A 87 37.724 52.072 58.087 1.00 23.75 C
ATOM 33 N ALA A 88 35.647 50.187 56.451 1.00 20.93 N
ATOM 34 CA ALA A 88 35.167 48.812 56.538 1.00 23.09 C
ATOM 35 C ALA A 88 35.484 48.210 57.908 1.00 18.55 C
ATOM 36 O ALA A 88 36.620 48.284 58.383 1.00 16.71 O
ATOM 37 CB ALA A 88 35.798 47.966 55.443 1.00 20.43 C
ATOM 38 N LEU A 89 34.467 47.621 58.529 1.00 19.97 N
ATOM 39 CA LEU A 89 34.614 47.000 59.836 1.00 20.00 C
ATOM 40 C LEU A 89 35.039 45.546 59.709 1.00 20.85 C
ATOM 41 O LEU A 89 35.639 44.990 60.628 1.00 21.75 O
ATOM 42 CB LEU A 89 33.298 47.103 60.606 1.00 22.49 C
ATOM 43 CG LEU A 89 32.773 48.538 60.750 1.00 22.30 C
ATOM 44 CD1 LEU A 89 31.372 48.534 61.331 1.00 20.82 C
ATOM 45 CD2 LEU A 89 33.728 49.331 61.626 1.00 18.34 C
ATOM 46 N TYR A 90 34.733 44.934 58.567 1.00 22.38 N
ATOM 47 CA TYR A 90 35.094 43.542 58.307 1.00 22.04 C
ATOM 48 C TYR A 90 35.534 43.372 56.865 1.00 21.97 C
ATOM 49 O TYR A 90 35.408 44.290 56.063 1.00 24.75 O
ATOM 50 CB TYR A 90 33.905 42.605 58.539 1.00 20.98 C
ATOM 51 CG TYR A 90 33.015 42.975 59.698 1.00 25.88 C
ATOM 52 CD1 TYR A 90 33.270 42.485 60.978 1.00 25.83 C
ATOM 53 CD2 TYR A 90 31.917 43.822 59.520 1.00 25.11 C
ATOM 54 CE1 TYR A 90 32.459 42.830 62.050 1.00 22.69 C
ATOM 55 CE2 TYR A 90 31.099 44.172 60.587 1.00 24.83 C
ATOM 56 CZ TYR A 90 31.381 43.671 61.849 1.00 27.24 C
ATOM 57 OH TYR A 90 30.586 44.014 62.915 1.00 35.67 O
ATOM 58 N ASP A 91 36.050 42.185 56.556 1.00 25.14 N
ATOM 59 CA ASP A 91 36.476 41.818 55.203 1.00 22.75 C
ATOM 60 C ASP A 91 35.197 41.370 54.511 1.00 21.32 C
ATOM 61 O ASP A 91 34.347 40.744 55.140 1.00 19.52 O
ATOM 62 CB ASP A 91 37.391 40.596 55.218 1.00 24.66 C
ATOM 63 CG ASP A 91 38.799 40.910 55.634 1.00 29.49 C
ATOM 64 OD1 ASP A 91 39.202 42.086 55.581 1.00 31.48 O
ATOM 65 OD2 ASP A 91 39.511 39.956 56.011 1.00 36.35 O
ATOM 66 N TYR A 92 35.051 41.673 53.229 1.00 20.02 N
ATOM 67 CA TYR A 92 33.869 41.222 52.502 1.00 19.74 C
ATOM 68 C TYR A 92 34.280 40.700 51.131 1.00 20.99 C
ATOM 69 O TYR A 92 35.025 41.354 50.404 1.00 23.49 O
ATOM 70 CB TYR A 92 32.850 42.351 52.334 1.00 18.08 C
ATOM 71 CG TYR A 92 31.657 41.972 51.474 1.00 18.94 C
ATOM 72 CD1 TYR A 92 30.621 41.198 51.990 1.00 15.94 C
ATOM 73 CD2 TYR A 92 31.568 42.382 50.138 1.00 18.73 C
ATOM 74 CE1 TYR A 92 29.528 40.837 51.208 1.00 17.20 C
ATOM 75 CE2 TYR A 92 30.476 42.026 49.344 1.00 17.82 C
ATOM 76 CZ TYR A 92 29.462 41.253 49.885 1.00 19.39 C
ATOM 77 OH TYR A 92 28.384 40.888 49.115 1.00 19.46 O
ATOM 78 N GLU A 93 33.803 39.512 50.785 1.00 20.75 N
ATOM 79 CA GLU A 93 34.115 38.927 49.492 1.00 24.04 C
ATOM 80 C GLU A 93 32.956 39.152 48.522 1.00 21.54 C
ATOM 81 O GLU A 93 31.794 38.916 48.852 1.00 18.19 O
ATOM 82 CB GLU A 93 34.390 37.431 49.641 1.00 31.98 C
ATOM 83 CG GLU A 93 35.856 37.061 49.525 1.00 46.50 C
ATOM 84 CD GLU A 93 36.445 37.456 48.176 1.00 55.46 C
ATOM 85 OE1 GLU A 93 35.748 37.293 47.147 1.00 57.59 O
ATOM 86 OE2 GLU A 93 37.604 37.933 48.147 1.00 57.81 O
ATOM 87 N SER A 94 33.279 39.617 47.323 1.00 19.44 N
ATOM 88 CA SER A 94 32.267 39.864 46.305 1.00 21.55 C
ATOM 89 C SER A 94 31.497 38.584 45.968 1.00 18.87 C
ATOM 90 O SER A 94 32.088 37.522 45.783 1.00 22.38 O
ATOM 91 CB SER A 94 32.930 40.415 45.036 1.00 19.57 C
ATOM 92 OG SER A 94 32.037 40.352 43.940 1.00 25.38 O
ATOM 93 N ARG A 95 30.178 38.698 45.878 1.00 20.39 N
ATOM 94 CA ARG A 95 29.319 37.560 45.563 1.00 21.98 C
ATOM 95 C ARG A 95 28.683 37.674 44.184 1.00 20.45 C
ATOM 96 O ARG A 95 28.151 36.699 43.662 1.00 17.95 O
ATOM 97 CB ARG A 95 28.200 37.442 46.596 1.00 21.74 C
ATOM 98 CG ARG A 95 28.639 37.672 48.022 1.00 20.11 C
ATOM 99 CD ARG A 95 27.428 37.759 48.927 1.00 19.98 C
ATOM 100 NE ARG A 95 27.792 37.622 50.329 1.00 20.65 N
ATOM 101 CZ ARG A 95 26.941 37.763 51.337 1.00 16.50 C
ATOM 102 NH1 ARG A 95 25.666 38.046 51.106 1.00 14.86 N
ATOM 103 NH2 ARG A 95 27.371 37.625 52.578 1.00 17.14 N
ATOM 104 N THR A 96 28.710 38.875 43.612 1.00 23.48 N
ATOM 105 CA THR A 96 28.121 39.102 42.301 1.00 21.89 C
ATOM 106 C THR A 96 29.005 39.943 41.399 1.00 23.17 C
ATOM 107 O THR A 96 30.118 40.324 41.752 1.00 22.36 O
ATOM 108 CB THR A 96 26.741 39.807 42.390 1.00 23.07 C
ATOM 109 OG1 THR A 96 26.931 41.199 42.661 1.00 24.11 O
ATOM 110 CG2 THR A 96 25.881 39.197 43.484 1.00 21.02 C
ATOM 111 N GLU A 97 28.468 40.230 40.224 1.00 26.47 N
ATOM 112 CA GLU A 97 29.140 41.019 39.205 1.00 29.05 C
ATOM 113 C GLU A 97 29.101 42.510 39.524 1.00 26.78 C
ATOM 114 O GLU A 97 29.938 43.276 39.047 1.00 25.68 O
ATOM 115 CB GLU A 97 28.443 40.774 37.864 1.00 34.39 C
ATOM 116 CG GLU A 97 29.149 41.343 36.664 1.00 45.45 C
ATOM 117 CD GLU A 97 30.182 40.385 36.111 1.00 53.87 C
ATOM 118 OE1 GLU A 97 30.399 39.322 36.740 1.00 55.21 O
ATOM 119 OE2 GLU A 97 30.774 40.698 35.054 1.00 57.33 O
ATOM 120 N THR A 98 28.134 42.923 40.339 1.00 25.26 N
ATOM 121 CA THR A 98 27.983 44.331 40.650 1.00 21.97 C
ATOM 122 C THR A 98 28.294 44.804 42.066 1.00 23.66 C
ATOM 123 O THR A 98 28.057 45.971 42.384 1.00 18.14 O
ATOM 124 CB THR A 98 26.575 44.796 40.284 1.00 22.67 C
ATOM 125 OG1 THR A 98 25.622 43.875 40.815 1.00 22.82 O
ATOM 126 CG2 THR A 98 26.408 44.835 38.765 1.00 20.09 C
ATOM 127 N ASP A 99 28.816 43.930 42.924 1.00 23.12 N
ATOM 128 CA ASP A 99 29.144 44.392 44.262 1.00 23.67 C
ATOM 129 C ASP A 99 30.634 44.598 44.387 1.00 22.26 C
ATOM 130 O ASP A 99 31.394 44.267 43.488 1.00 22.97 O
ATOM 131 CB ASP A 99 28.608 43.446 45.350 1.00 22.86 C
ATOM 132 CG ASP A 99 29.162 42.052 45.259 1.00 26.00 C
ATOM 133 OD1 ASP A 99 29.984 41.768 44.364 1.00 28.61 O
ATOM 134 OD2 ASP A 99 28.763 41.223 46.104 1.00 27.89 O
ATOM 135 N LEU A 100 31.052 45.156 45.509 1.00 24.34 N
ATOM 136 CA LEU A 100 32.452 45.451 45.719 1.00 22.07 C
ATOM 137 C LEU A 100 33.061 44.725 46.909 1.00 23.63 C
ATOM 138 O LEU A 100 32.514 44.754 48.009 1.00 23.96 O
ATOM 139 CB LEU A 100 32.600 46.960 45.900 1.00 23.29 C
ATOM 140 CG LEU A 100 33.898 47.527 46.450 1.00 20.33 C
ATOM 141 CD1 LEU A 100 34.973 47.437 45.385 1.00 22.82 C
ATOM 142 CD2 LEU A 100 33.675 48.976 46.885 1.00 21.51 C
ATOM 143 N SER A 101 34.201 44.082 46.671 1.00 23.80 N
ATOM 144 CA SER A 101 34.943 43.361 47.704 1.00 24.56 C
ATOM 145 C SER A 101 35.828 44.371 48.431 1.00 24.51 C
ATOM 146 O SER A 101 36.267 45.355 47.838 1.00 23.86 O
ATOM 147 CB SER A 101 35.857 42.302 47.075 1.00 25.67 C
ATOM 148 OG SER A 101 35.158 41.111 46.774 1.00 35.72 O
ATOM 149 N PHE A 102 36.100 44.129 49.708 1.00 21.87 N
ATOM 150 CA PHE A 102 36.968 45.018 50.468 1.00 18.36 C
ATOM 151 C PHE A 102 37.520 44.310 51.691 1.00 19.95 C
ATOM 152 O PHE A 102 37.015 43.261 52.107 1.00 18.05 O
ATOM 153 CB PHE A 102 36.230 46.301 50.883 1.00 15.39 C
ATOM 154 CG PHE A 102 34.939 46.062 51.627 1.00 17.29 C
ATOM 155 CD1 PHE A 102 34.932 45.894 53.008 1.00 18.80 C
ATOM 156 CD2 PHE A 102 33.722 46.038 50.948 1.00 17.46 C
ATOM 157 CE1 PHE A 102 33.728 45.708 53.700 1.00 18.47 C
ATOM 158 CE2 PHE A 102 32.511 45.852 51.628 1.00 17.31 C
ATOM 159 CZ PHE A 102 32.513 45.687 53.008 1.00 18.06 C
ATOM 160 N LYS A 103 38.576 44.884 52.250 1.00 20.68 N
ATOM 161 CA LYS A 103 39.218 44.331 53.424 1.00 22.78 C
ATOM 162 C LYS A 103 39.012 45.274 54.598 1.00 24.03 C
ATOM 163 O LYS A 103 38.872 46.483 54.424 1.00 22.60 O
ATOM 164 CB LYS A 103 40.711 44.124 53.157 1.00 27.31 C
ATOM 165 CG LYS A 103 41.637 44.547 54.293 1.00 38.68 C
ATOM 166 CD LYS A 103 42.812 43.575 54.455 1.00 44.45 C
ATOM 167 CE LYS A 103 43.852 44.092 55.452 1.00 47.79 C
ATOM 168 NZ LYS A 103 43.248 44.573 56.736 1.00 47.98 N
ATOM 169 N LYS A 104 38.970 44.702 55.792 1.00 24.72 N
ATOM 170 CA LYS A 104 38.796 45.468 57.016 1.00 24.65 C
ATOM 171 C LYS A 104 39.759 46.656 57.030 1.00 23.49 C
ATOM 172 O LYS A 104 40.937 46.501 56.728 1.00 25.64 O
ATOM 173 CB LYS A 104 39.069 44.563 58.216 1.00 21.15 C
ATOM 174 CG LYS A 104 39.119 45.277 59.540 1.00 21.77 C
ATOM 175 CD LYS A 104 39.182 44.272 60.662 1.00 22.28 C
ATOM 176 CE LYS A 104 39.196 44.960 62.001 1.00 27.90 C
ATOM 177 NZ LYS A 104 39.345 43.965 63.096 1.00 35.99 N
ATOM 178 N GLY A 105 39.255 47.841 57.360 1.00 23.79 N
ATOM 179 CA GLY A 105 40.126 49.004 57.409 1.00 26.77 C
ATOM 180 C GLY A 105 40.227 49.826 56.132 1.00 27.73 C
ATOM 181 O GLY A 105 40.820 50.907 56.135 1.00 27.29 O
ATOM 182 N GLU A 106 39.660 49.320 55.042 1.00 29.01 N
ATOM 183 CA GLU A 106 39.676 50.027 53.763 1.00 29.02 C
ATOM 184 C GLU A 106 38.757 51.233 53.866 1.00 27.74 C
ATOM 185 O GLU A 106 37.688 51.150 54.472 1.00 27.88 O
ATOM 186 CB GLU A 106 39.173 49.107 52.645 1.00 29.26 C
ATOM 187 CG GLU A 106 39.497 49.570 51.228 1.00 30.57 C
ATOM 188 CD GLU A 106 39.318 48.458 50.197 1.00 31.58 C
ATOM 189 OE1 GLU A 106 39.585 47.284 50.534 1.00 25.60 O
ATOM 190 OE2 GLU A 106 38.911 48.752 49.050 1.00 32.73 O
ATOM 191 N ARG A 107 39.174 52.350 53.274 1.00 28.02 N
ATOM 192 CA ARG A 107 38.380 53.573 53.280 1.00 29.01 C
ATOM 193 C ARG A 107 37.474 53.573 52.059 1.00 27.65 C
ATOM 194 O ARG A 107 37.915 53.274 50.949 1.00 29.49 O
ATOM 195 CB ARG A 107 39.291 54.793 53.248 1.00 34.84 C
ATOM 196 CG ARG A 107 39.115 55.705 54.439 1.00 46.02 C
ATOM 197 CD ARG A 107 40.393 56.476 54.722 1.00 54.20 C
ATOM 198 NE ARG A 107 40.791 57.332 53.603 1.00 59.61 N
ATOM 199 CZ ARG A 107 40.279 58.535 53.353 1.00 62.36 C
ATOM 200 NH1 ARG A 107 39.335 59.042 54.138 1.00 63.25 N
ATOM 201 NH2 ARG A 107 40.709 59.235 52.310 1.00 64.54 N
ATOM 202 N LEU A 108 36.208 53.913 52.255 1.00 27.60 N
ATOM 203 CA LEU A 108 35.263 53.906 51.152 1.00 28.42 C
ATOM 204 C LEU A 108 34.391 55.139 51.086 1.00 29.80 C
ATOM 205 O LEU A 108 34.013 55.703 52.111 1.00 31.09 O
ATOM 206 CB LEU A 108 34.357 52.676 51.249 1.00 29.17 C
ATOM 207 CG LEU A 108 35.024 51.347 51.612 1.00 28.55 C
ATOM 208 CD1 LEU A 108 34.047 50.481 52.384 1.00 27.47 C
ATOM 209 CD2 LEU A 108 35.491 50.654 50.344 1.00 26.42 C
ATOM 210 N GLN A 109 34.064 55.543 49.865 1.00 26.83 N
ATOM 211 CA GLN A 109 33.202 56.688 49.644 1.00 25.71 C
ATOM 212 C GLN A 109 31.828 56.183 49.218 1.00 26.49 C
ATOM 213 O GLN A 109 31.698 55.554 48.172 1.00 31.17 O
ATOM 214 CB GLN A 109 33.781 57.587 48.545 1.00 23.78 C
ATOM 215 CG GLN A 109 33.014 58.881 48.342 1.00 24.20 C
ATOM 216 CD GLN A 109 33.349 59.929 49.392 1.00 22.77 C
ATOM 217 OE1 GLN A 109 32.498 60.723 49.787 1.00 23.39 O
ATOM 218 NE2 GLN A 109 34.591 59.931 49.847 1.00 22.20 N
ATOM 219 N ILE A 110 30.806 56.434 50.032 1.00 22.95 N
ATOM 220 CA ILE A 110 29.456 56.014 49.681 1.00 24.36 C
ATOM 221 C ILE A 110 28.965 57.019 48.632 1.00 28.65 C
ATOM 222 O ILE A 110 28.565 58.140 48.961 1.00 25.68 O
ATOM 223 CB ILE A 110 28.503 56.040 50.899 1.00 22.62 C
ATOM 224 CG1 ILE A 110 29.119 55.274 52.077 1.00 23.69 C
ATOM 225 CG2 ILE A 110 27.161 55.449 50.520 1.00 22.99 C
ATOM 226 CD1 ILE A 110 29.565 53.859 51.760 1.00 22.52 C
ATOM 227 N VAL A 111 29.006 56.604 47.367 1.00 30.03 N
ATOM 228 CA VAL A 111 28.606 57.454 46.249 1.00 27.29 C
ATOM 229 C VAL A 111 27.118 57.392 45.912 1.00 27.44 C
ATOM 230 O VAL A 111 26.672 57.894 44.881 1.00 25.06 O
ATOM 231 CB VAL A 111 29.457 57.120 45.010 1.00 26.22 C
ATOM 232 CG1 VAL A 111 30.925 57.314 45.347 1.00 25.22 C
ATOM 233 CG2 VAL A 111 29.214 55.687 44.572 1.00 21.26 C
ATOM 234 N ASN A 112 26.352 56.787 46.806 1.00 29.95 N
ATOM 235 CA ASN A 112 24.906 56.665 46.656 1.00 35.70 C
ATOM 236 C ASN A 112 24.420 55.808 47.819 1.00 39.87 C
ATOM 237 O ASN A 112 24.739 54.619 47.905 1.00 39.79 O
ATOM 238 CB ASN A 112 24.549 55.998 45.322 1.00 37.04 C
ATOM 239 CG ASN A 112 23.098 56.218 44.927 1.00 36.43 C
ATOM 240 OD1 ASN A 112 22.215 56.299 45.782 1.00 37.46 O
ATOM 241 ND2 ASN A 112 22.845 56.319 43.625 1.00 34.49 N
ATOM 242 N ASN A 113 23.659 56.414 48.721 1.00 43.17 N
ATOM 243 CA ASN A 113 23.152 55.695 49.884 1.00 49.22 C
ATOM 244 C ASN A 113 21.639 55.717 49.912 1.00 48.66 C
ATOM 245 O ASN A 113 21.032 55.481 50.954 1.00 48.30 O
ATOM 246 CB ASN A 113 23.690 56.329 51.169 1.00 55.65 C
ATOM 247 CG ASN A 113 23.521 57.845 51.188 1.00 62.53 C
ATOM 248 OD1 ASN A 113 22.704 58.402 50.448 1.00 66.29 O
ATOM 249 ND2 ASN A 113 24.296 58.519 52.038 1.00 66.09 N
ATOM 250 N THR A 114 21.035 56.006 48.765 1.00 51.13 N
ATOM 251 CA THR A 114 19.583 56.078 48.651 1.00 55.69 C
ATOM 252 C THR A 114 18.893 54.733 48.884 1.00 57.21 C
ATOM 253 O THR A 114 17.696 54.588 48.633 1.00 57.09 O
ATOM 254 CB THR A 114 19.160 56.640 47.266 1.00 56.65 C
ATOM 255 OG1 THR A 114 19.730 55.846 46.218 1.00 56.53 O
ATOM 256 CG2 THR A 114 19.639 58.081 47.114 1.00 57.81 C
ATOM 257 N GLU A 115 19.654 53.757 49.375 1.00 60.69 N
ATOM 258 CA GLU A 115 19.121 52.423 49.651 1.00 61.91 C
ATOM 259 C GLU A 115 18.985 52.191 51.157 1.00 61.16 C
ATOM 260 O GLU A 115 18.857 53.142 51.932 1.00 63.30 O
ATOM 261 CB GLU A 115 20.033 51.351 49.043 1.00 64.19 C
ATOM 262 CG GLU A 115 20.154 51.413 47.523 1.00 63.78 C
ATOM 263 CD GLU A 115 21.342 52.246 47.055 1.00 63.59 C
ATOM 264 OE1 GLU A 115 22.216 52.573 47.889 1.00 59.11 O
ATOM 265 OE2 GLU A 115 21.399 52.576 45.848 1.00 63.33 O
ATOM 266 N GLY A 116 19.017 50.926 51.566 1.00 57.77 N
ATOM 267 CA GLY A 116 18.883 50.608 52.975 1.00 52.88 C
ATOM 268 C GLY A 116 19.953 49.667 53.492 1.00 49.38 C
ATOM 269 O GLY A 116 20.730 50.025 54.379 1.00 49.99 O
ATOM 270 N ASP A 117 19.994 48.458 52.939 1.00 46.99 N
ATOM 271 CA ASP A 117 20.974 47.460 53.359 1.00 42.14 C
ATOM 272 C ASP A 117 22.151 47.332 52.381 1.00 36.31 C
ATOM 273 O ASP A 117 23.216 46.835 52.747 1.00 32.26 O
ATOM 274 CB ASP A 117 20.288 46.099 53.546 1.00 44.48 C
ATOM 275 CG ASP A 117 19.015 46.189 54.387 1.00 47.09 C
ATOM 276 OD1 ASP A 117 18.984 46.975 55.361 1.00 46.65 O
ATOM 277 OD2 ASP A 117 18.042 45.468 54.072 1.00 50.30 O
ATOM 278 N TRP A 118 21.956 47.780 51.142 1.00 32.62 N
ATOM 279 CA TRP A 118 23.015 47.724 50.135 1.00 28.22 C
ATOM 280 C TRP A 118 23.241 49.124 49.569 1.00 27.49 C
ATOM 281 O TRP A 118 22.335 49.736 49.009 1.00 28.13 O
ATOM 282 CB TRP A 118 22.652 46.721 49.023 1.00 23.95 C
ATOM 283 CG TRP A 118 22.603 45.269 49.518 1.00 23.44 C
ATOM 284 CD1 TRP A 118 21.510 44.603 49.998 1.00 22.42 C
ATOM 285 CD2 TRP A 118 23.700 44.343 49.614 1.00 21.84 C
ATOM 286 NE1 TRP A 118 21.855 43.328 50.389 1.00 20.63 N
ATOM 287 CE2 TRP A 118 23.192 43.140 50.162 1.00 20.80 C
ATOM 288 CE3 TRP A 118 25.062 44.412 49.289 1.00 21.20 C
ATOM 289 CZ2 TRP A 118 23.996 42.017 50.395 1.00 21.49 C
ATOM 290 CZ3 TRP A 118 25.865 43.290 49.522 1.00 24.54 C
ATOM 291 CH2 TRP A 118 25.324 42.108 50.069 1.00 21.56 C
ATOM 292 N TRP A 119 24.461 49.627 49.745 1.00 27.70 N
ATOM 293 CA TRP A 119 24.855 50.961 49.286 1.00 25.62 C
ATOM 294 C TRP A 119 25.883 50.886 48.166 1.00 22.08 C
ATOM 295 O TRP A 119 26.728 49.992 48.156 1.00 19.78 O
ATOM 296 CB TRP A 119 25.515 51.747 50.420 1.00 25.14 C
ATOM 297 CG TRP A 119 24.667 52.039 51.605 1.00 26.50 C
ATOM 298 CD1 TRP A 119 23.307 51.945 51.698 1.00 26.91 C
ATOM 299 CD2 TRP A 119 25.125 52.542 52.866 1.00 24.88 C
ATOM 300 NE1 TRP A 119 22.891 52.367 52.941 1.00 27.32 N
ATOM 301 CE2 TRP A 119 23.989 52.740 53.676 1.00 26.66 C
ATOM 302 CE3 TRP A 119 26.393 52.849 53.388 1.00 23.92 C
ATOM 303 CZ2 TRP A 119 24.077 53.233 54.988 1.00 26.44 C
ATOM 304 CZ3 TRP A 119 26.482 53.341 54.690 1.00 25.15 C
ATOM 305 CH2 TRP A 119 25.330 53.527 55.474 1.00 23.98 C
ATOM 306 N LEU A 120 25.835 51.849 47.247 1.00 22.59 N
ATOM 307 CA LEU A 120 26.813 51.906 46.170 1.00 19.11 C
ATOM 308 C LEU A 120 28.040 52.602 46.759 1.00 18.06 C
ATOM 309 O LEU A 120 27.929 53.688 47.324 1.00 21.84 O
ATOM 310 CB LEU A 120 26.259 52.702 44.987 1.00 22.67 C
ATOM 311 CG LEU A 120 27.065 52.612 43.689 1.00 25.24 C
ATOM 312 CD1 LEU A 120 27.181 51.147 43.239 1.00 23.56 C
ATOM 313 CD2 LEU A 120 26.384 53.455 42.622 1.00 20.80 C
ATOM 314 N ALA A 121 29.203 51.972 46.641 1.00 16.70 N
ATOM 315 CA ALA A 121 30.430 52.520 47.197 1.00 19.75 C
ATOM 316 C ALA A 121 31.583 52.533 46.200 1.00 23.06 C
ATOM 317 O ALA A 121 31.555 51.836 45.183 1.00 25.31 O
ATOM 318 CB ALA A 121 30.831 51.719 48.443 1.00 18.88 C
ATOM 319 N HIS A 122 32.606 53.320 46.520 1.00 23.79 N
ATOM 320 CA HIS A 122 33.787 53.462 45.682 1.00 23.98 C
ATOM 321 C HIS A 122 35.003 53.373 46.594 1.00 23.65 C
ATOM 322 O HIS A 122 35.138 54.167 47.523 1.00 25.16 O
ATOM 323 CB HIS A 122 33.739 54.828 44.970 1.00 27.31 C
ATOM 324 CG HIS A 122 34.887 55.080 44.040 1.00 28.86 C
ATOM 325 ND1 HIS A 122 35.442 56.330 43.870 1.00 29.46 N
ATOM 326 CD2 HIS A 122 35.573 54.253 43.217 1.00 31.49 C
ATOM 327 CE1 HIS A 122 36.419 56.262 42.984 1.00 30.18 C
ATOM 328 NE2 HIS A 122 36.519 55.010 42.571 1.00 29.92 N
ATOM 329 N SER A 123 35.877 52.401 46.341 1.00 23.65 N
ATOM 330 CA SER A 123 37.078 52.219 47.155 1.00 27.88 C
ATOM 331 C SER A 123 38.120 53.290 46.854 1.00 30.62 C
ATOM 332 O SER A 123 38.549 53.464 45.710 1.00 32.41 O
ATOM 333 CB SER A 123 37.687 50.826 46.929 1.00 27.95 C
ATOM 334 OG SER A 123 39.004 50.744 47.457 1.00 28.50 O
ATOM 335 N LEU A 124 38.530 54.002 47.896 1.00 29.56 N
ATOM 336 CA LEU A 124 39.510 55.054 47.750 1.00 30.69 C
ATOM 337 C LEU A 124 40.922 54.505 47.551 1.00 31.95 C
ATOM 338 O LEU A 124 41.820 55.235 47.130 1.00 35.25 O
ATOM 339 CB LEU A 124 39.446 55.979 48.970 1.00 29.88 C
ATOM 340 CG LEU A 124 38.098 56.694 49.131 1.00 31.37 C
ATOM 341 CD1 LEU A 124 38.000 57.322 50.511 1.00 33.66 C
ATOM 342 CD2 LEU A 124 37.947 57.756 48.049 1.00 28.42 C
ATOM 343 N SER A 125 41.121 53.218 47.828 1.00 32.82 N
ATOM 344 CA SER A 125 42.446 52.612 47.668 1.00 33.38 C
ATOM 345 C SER A 125 42.606 51.848 46.353 1.00 31.63 C
ATOM 346 O SER A 125 43.674 51.871 45.747 1.00 31.67 O
ATOM 347 CB SER A 125 42.764 51.672 48.845 1.00 33.38 C
ATOM 348 OG SER A 125 41.586 51.222 49.497 1.00 38.17 O
ATOM 349 N THR A 126 41.544 51.179 45.919 1.00 31.26 N
ATOM 350 CA THR A 126 41.582 50.401 44.686 1.00 30.20 C
ATOM 351 C THR A 126 40.947 51.120 43.504 1.00 28.98 C
ATOM 352 O THR A 126 41.303 50.869 42.354 1.00 30.78 O
ATOM 353 CB THR A 126 40.855 49.073 44.868 1.00 27.61 C
ATOM 354 OG1 THR A 126 39.444 49.309 44.939 1.00 29.19 O
ATOM 355 CG2 THR A 126 41.306 48.403 46.147 1.00 30.87 C
ATOM 356 N GLY A 127 40.001 52.007 43.794 1.00 28.44 N
ATOM 357 CA GLY A 127 39.322 52.741 42.746 1.00 28.53 C
ATOM 358 C GLY A 127 38.125 51.977 42.209 1.00 32.33 C
ATOM 359 O GLY A 127 37.392 52.489 41.362 1.00 33.46 O
ATOM 360 N GLN A 128 37.924 50.753 42.701 1.00 34.19 N
ATOM 361 CA GLN A 128 36.802 49.913 42.267 1.00 31.80 C
ATOM 362 C GLN A 128 35.486 50.417 42.845 1.00 29.47 C
ATOM 363 O GLN A 128 35.463 51.029 43.908 1.00 30.12 O
ATOM 364 CB GLN A 128 37.013 48.458 42.706 1.00 36.10 C
ATOM 365 CG GLN A 128 38.402 47.902 42.441 1.00 44.93 C
ATOM 366 CD GLN A 128 38.762 47.907 40.968 1.00 52.80 C
ATOM 367 OE1 GLN A 128 37.912 47.650 40.109 1.00 56.91 O
ATOM 368 NE2 GLN A 128 40.028 48.203 40.666 1.00 55.50 N
ATOM 369 N THR A 129 34.391 50.157 42.143 1.00 26.31 N
ATOM 370 CA THR A 129 33.078 50.587 42.598 1.00 27.37 C
ATOM 371 C THR A 129 32.172 49.375 42.735 1.00 27.05 C
ATOM 372 O THR A 129 32.484 48.308 42.220 1.00 31.71 O
ATOM 373 CB THR A 129 32.439 51.561 41.594 1.00 32.07 C
ATOM 374 OG1 THR A 129 32.190 50.875 40.361 1.00 36.00 O
ATOM 375 CG2 THR A 129 33.366 52.745 41.327 1.00 33.75 C
ATOM 376 N GLY A 130 31.051 49.531 43.429 1.00 24.65 N
ATOM 377 CA GLY A 130 30.145 48.408 43.582 1.00 25.93 C
ATOM 378 C GLY A 130 29.353 48.431 44.869 1.00 23.92 C
ATOM 379 O GLY A 130 29.701 49.162 45.794 1.00 24.89 O
ATOM 380 N TYR A 131 28.290 47.632 44.925 1.00 21.25 N
ATOM 381 CA TYR A 131 27.443 47.563 46.108 1.00 21.73 C
ATOM 382 C TYR A 131 28.115 46.866 47.289 1.00 19.48 C
ATOM 383 O TYR A 131 28.918 45.946 47.125 1.00 16.22 O
ATOM 384 CB TYR A 131 26.130 46.852 45.782 1.00 24.42 C
ATOM 385 CG TYR A 131 25.188 47.690 44.950 1.00 29.63 C
ATOM 386 CD1 TYR A 131 24.550 48.803 45.499 1.00 29.48 C
ATOM 387 CD2 TYR A 131 24.952 47.386 43.608 1.00 26.83 C
ATOM 388 CE1 TYR A 131 23.703 49.595 44.734 1.00 34.92 C
ATOM 389 CE2 TYR A 131 24.108 48.169 42.832 1.00 30.52 C
ATOM 390 CZ TYR A 131 23.486 49.275 43.399 1.00 35.80 C
ATOM 391 OH TYR A 131 22.650 50.065 42.636 1.00 38.38 O
ATOM 392 N ILE A 132 27.776 47.328 48.486 1.00 18.10 N
ATOM 393 CA ILE A 132 28.327 46.764 49.708 1.00 19.69 C
ATOM 394 C ILE A 132 27.235 46.629 50.777 1.00 17.90 C
ATOM 395 O ILE A 132 26.214 47.318 50.729 1.00 16.94 O
ATOM 396 CB ILE A 132 29.447 47.668 50.284 1.00 17.94 C
ATOM 397 CG1 ILE A 132 28.887 49.067 50.556 1.00 22.40 C
ATOM 398 CG2 ILE A 132 30.628 47.736 49.335 1.00 19.15 C
ATOM 399 CD1 ILE A 132 29.408 49.703 51.829 1.00 23.36 C
ATOM 400 N PRO A 133 27.418 45.709 51.736 1.00 15.38 N
ATOM 401 CA PRO A 133 26.397 45.574 52.784 1.00 19.81 C
ATOM 402 C PRO A 133 26.581 46.756 53.765 1.00 18.65 C
ATOM 403 O PRO A 133 27.667 46.951 54.320 1.00 18.75 O
ATOM 404 CB PRO A 133 26.701 44.219 53.424 1.00 16.52 C
ATOM 405 CG PRO A 133 28.104 43.898 53.046 1.00 15.12 C
ATOM 406 CD PRO A 133 28.531 44.760 51.893 1.00 14.97 C
ATOM 407 N SER A 134 25.535 47.552 53.956 1.00 19.81 N
ATOM 408 CA SER A 134 25.637 48.718 54.832 1.00 24.12 C
ATOM 409 C SER A 134 26.114 48.422 56.259 1.00 26.36 C
ATOM 410 O SER A 134 26.724 49.289 56.893 1.00 24.30 O
ATOM 411 CB SER A 134 24.302 49.483 54.871 1.00 20.47 C
ATOM 412 OG SER A 134 23.270 48.733 55.483 1.00 21.68 O
ATOM 413 N ASN A 135 25.860 47.207 56.754 1.00 26.00 N
ATOM 414 CA ASN A 135 26.275 46.827 58.108 1.00 23.25 C
ATOM 415 C ASN A 135 27.730 46.378 58.233 1.00 21.88 C
ATOM 416 O ASN A 135 28.124 45.822 59.256 1.00 23.94 O
ATOM 417 CB ASN A 135 25.347 45.743 58.681 1.00 24.95 C
ATOM 418 CG ASN A 135 25.242 44.506 57.799 1.00 26.44 C
ATOM 419 OD1 ASN A 135 24.928 43.423 58.283 1.00 30.46 O
ATOM 420 ND2 ASN A 135 25.491 44.663 56.512 1.00 31.59 N
ATOM 421 N TYR A 136 28.532 46.641 57.204 1.00 18.83 N
ATOM 422 CA TYR A 136 29.941 46.262 57.224 1.00 16.97 C
ATOM 423 C TYR A 136 30.860 47.485 57.295 1.00 14.32 C
ATOM 424 O TYR A 136 32.080 47.351 57.324 1.00 16.63 O
ATOM 425 CB TYR A 136 30.285 45.438 55.975 1.00 18.90 C
ATOM 426 CG TYR A 136 30.039 43.939 56.098 1.00 17.35 C
ATOM 427 CD1 TYR A 136 28.786 43.437 56.471 1.00 16.86 C
ATOM 428 CD2 TYR A 136 31.060 43.023 55.813 1.00 19.30 C
ATOM 429 CE1 TYR A 136 28.553 42.060 56.558 1.00 16.27 C
ATOM 430 CE2 TYR A 136 30.838 41.645 55.896 1.00 21.11 C
ATOM 431 CZ TYR A 136 29.586 41.173 56.270 1.00 18.69 C
ATOM 432 OH TYR A 136 29.384 39.819 56.370 1.00 21.06 O
ATOM 433 N VAL A 137 30.271 48.676 57.333 1.00 17.32 N
ATOM 434 CA VAL A 137 31.055 49.911 57.383 1.00 19.69 C
ATOM 435 C VAL A 137 30.548 50.888 58.438 1.00 20.30 C
ATOM 436 O VAL A 137 29.415 50.779 58.912 1.00 19.10 O
ATOM 437 CB VAL A 137 31.026 50.677 56.024 1.00 18.58 C
ATOM 438 CG1 VAL A 137 31.588 49.799 54.909 1.00 20.04 C
ATOM 439 CG2 VAL A 137 29.602 51.139 55.718 1.00 12.67 C
ATOM 440 N ALA A 138 31.398 51.851 58.783 1.00 21.41 N
ATOM 441 CA ALA A 138 31.041 52.885 59.752 1.00 23.41 C
ATOM 442 C ALA A 138 31.706 54.194 59.356 1.00 21.94 C
ATOM 443 O ALA A 138 32.767 54.203 58.724 1.00 20.25 O
ATOM 444 CB ALA A 138 31.487 52.490 61.153 1.00 20.76 C
ATOM 445 N PRO A 139 31.084 55.324 59.715 1.00 23.30 N
ATOM 446 CA PRO A 139 31.677 56.616 59.368 1.00 23.05 C
ATOM 447 C PRO A 139 33.081 56.700 59.932 1.00 24.29 C
ATOM 448 O PRO A 139 33.327 56.270 61.056 1.00 26.48 O
ATOM 449 CB PRO A 139 30.732 57.628 60.010 1.00 18.60 C
ATOM 450 CG PRO A 139 29.443 56.905 60.121 1.00 20.55 C
ATOM 451 CD PRO A 139 29.806 55.484 60.422 1.00 20.03 C
ATOM 452 N SER A 140 34.006 57.228 59.144 1.00 24.94 N
ATOM 453 CA SER A 140 35.381 57.373 59.592 1.00 28.22 C
ATOM 454 C SER A 140 35.387 58.228 60.858 1.00 31.36 C
ATOM 455 O SER A 140 34.599 59.162 60.984 1.00 32.01 O
ATOM 456 CB SER A 140 36.221 58.053 58.509 1.00 28.69 C
ATOM 457 OG SER A 140 36.964 57.111 57.757 1.00 31.69 O
ATOM 458 N ASP A 141 36.263 57.891 61.799 1.00 35.41 N
ATOM 459 CA ASP A 141 36.389 58.635 63.052 1.00 38.34 C
ATOM 460 C ASP A 141 35.188 58.597 64.004 1.00 35.14 C
ATOM 461 O ASP A 141 35.166 59.316 65.008 1.00 31.47 O
ATOM 462 CB ASP A 141 36.761 60.091 62.756 1.00 46.87 C
ATOM 463 CG ASP A 141 38.269 60.305 62.685 1.00 55.22 C
ATOM 464 OD1 ASP A 141 39.008 59.652 63.461 1.00 60.52 O
ATOM 465 OD2 ASP A 141 38.715 61.128 61.853 1.00 61.25 O
ATOM 466 N SER A 142 34.189 57.775 63.691 1.00 31.23 N
ATOM 467 CA SER A 142 33.032 57.642 64.571 1.00 29.09 C
ATOM 468 C SER A 142 33.455 56.638 65.650 1.00 29.68 C
ATOM 469 O SER A 142 34.513 56.004 65.521 1.00 27.29 O
ATOM 470 CB SER A 142 31.808 57.121 63.799 1.00 27.47 C
ATOM 471 OG SER A 142 31.978 55.783 63.354 1.00 27.39 O
ATOM 472 N ILE A 143 32.666 56.504 66.717 1.00 26.17 N
ATOM 473 CA ILE A 143 33.019 55.549 67.771 1.00 24.77 C
ATOM 474 C ILE A 143 32.713 54.149 67.234 1.00 23.81 C
ATOM 475 O ILE A 143 33.388 53.179 67.570 1.00 23.05 O
ATOM 476 CB ILE A 143 32.233 55.827 69.084 1.00 19.68 C
ATOM 477 CG1 ILE A 143 32.642 54.831 70.171 1.00 19.13 C
ATOM 478 CG2 ILE A 143 30.748 55.736 68.834 1.00 19.21 C
ATOM 479 CD1 ILE A 143 34.086 54.907 70.556 1.00 14.55 C
ATOM 480 N GLN A 144 31.703 54.061 66.374 1.00 23.92 N
ATOM 481 CA GLN A 144 31.326 52.791 65.756 1.00 26.23 C
ATOM 482 C GLN A 144 32.451 52.287 64.864 1.00 27.03 C
ATOM 483 O GLN A 144 32.499 51.109 64.516 1.00 30.42 O
ATOM 484 CB GLN A 144 30.077 52.956 64.901 1.00 26.47 C
ATOM 485 CG GLN A 144 28.793 53.004 65.685 1.00 30.68 C
ATOM 486 CD GLN A 144 28.468 54.403 66.133 1.00 33.42 C
ATOM 487 OE1 GLN A 144 29.157 55.357 65.764 1.00 33.86 O
ATOM 488 NE2 GLN A 144 27.419 54.541 66.935 1.00 37.21 N
ATOM 489 N ALA A 145 33.351 53.182 64.478 1.00 24.10 N
ATOM 490 CA ALA A 145 34.462 52.790 63.634 1.00 23.19 C
ATOM 491 C ALA A 145 35.511 52.058 64.467 1.00 24.95 C
ATOM 492 O ALA A 145 36.367 51.371 63.917 1.00 24.43 O
ATOM 493 CB ALA A 145 35.078 54.020 62.964 1.00 21.54 C
ATOM 494 N GLU A 146 35.445 52.201 65.790 1.00 23.89 N
ATOM 495 CA GLU A 146 36.415 51.546 66.668 1.00 22.30 C
ATOM 496 C GLU A 146 36.236 50.037 66.655 1.00 20.27 C
ATOM 497 O GLU A 146 35.125 49.532 66.785 1.00 20.53 O
ATOM 498 CB GLU A 146 36.289 52.059 68.104 1.00 24.10 C
ATOM 499 CG GLU A 146 36.811 53.470 68.315 1.00 29.51 C
ATOM 500 CD GLU A 146 38.217 53.666 67.790 1.00 34.13 C
ATOM 501 OE1 GLU A 146 39.074 52.793 68.028 1.00 39.82 O
ATOM 502 OE2 GLU A 146 38.472 54.698 67.136 1.00 39.10 O
ATOM 503 N GLU A 147 37.350 49.332 66.503 1.00 20.26 N
ATOM 504 CA GLU A 147 37.384 47.878 66.446 1.00 23.63 C
ATOM 505 C GLU A 147 36.830 47.221 67.712 1.00 22.35 C
ATOM 506 O GLU A 147 36.198 46.166 67.658 1.00 20.14 O
ATOM 507 CB GLU A 147 38.827 47.444 66.225 1.00 26.03 C
ATOM 508 CG GLU A 147 38.997 46.065 65.685 1.00 36.06 C
ATOM 509 CD GLU A 147 40.433 45.606 65.789 1.00 42.31 C
ATOM 510 OE1 GLU A 147 41.292 46.426 66.189 1.00 42.62 O
ATOM 511 OE2 GLU A 147 40.703 44.428 65.476 1.00 47.52 O
ATOM 512 N TRP A 148 37.063 47.859 68.849 1.00 20.32 N
ATOM 513 CA TRP A 148 36.608 47.331 70.125 1.00 21.14 C
ATOM 514 C TRP A 148 35.223 47.824 70.583 1.00 22.33 C
ATOM 515 O TRP A 148 34.751 47.445 71.656 1.00 22.10 O
ATOM 516 CB TRP A 148 37.655 47.662 71.189 1.00 19.39 C
ATOM 517 CG TRP A 148 38.276 49.010 71.008 1.00 19.41 C
ATOM 518 CD1 TRP A 148 39.500 49.285 70.475 1.00 19.78 C
ATOM 519 CD2 TRP A 148 37.705 50.276 71.379 1.00 20.45 C
ATOM 520 NE1 TRP A 148 39.731 50.641 70.491 1.00 22.89 N
ATOM 521 CE2 TRP A 148 38.646 51.274 71.042 1.00 21.29 C
ATOM 522 CE3 TRP A 148 36.489 50.661 71.967 1.00 21.83 C
ATOM 523 CZ2 TRP A 148 38.413 52.640 71.272 1.00 20.76 C
ATOM 524 CZ3 TRP A 148 36.256 52.021 72.198 1.00 22.87 C
ATOM 525 CH2 TRP A 148 37.219 52.991 71.848 1.00 21.77 C
ATOM 526 N TYR A 149 34.568 48.658 69.777 1.00 21.90 N
ATOM 527 CA TYR A 149 33.254 49.178 70.150 1.00 20.22 C
ATOM 528 C TYR A 149 32.125 48.299 69.621 1.00 23.01 C
ATOM 529 O TYR A 149 31.831 48.300 68.423 1.00 24.16 O
ATOM 530 CB TYR A 149 33.082 50.610 69.634 1.00 20.55 C
ATOM 531 CG TYR A 149 31.817 51.252 70.144 1.00 22.59 C
ATOM 532 CD1 TYR A 149 31.734 51.711 71.460 1.00 22.05 C
ATOM 533 CD2 TYR A 149 30.684 51.346 69.338 1.00 16.80 C
ATOM 534 CE1 TYR A 149 30.557 52.240 71.959 1.00 22.28 C
ATOM 535 CE2 TYR A 149 29.502 51.875 69.830 1.00 20.11 C
ATOM 536 CZ TYR A 149 29.445 52.317 71.145 1.00 21.35 C
ATOM 537 OH TYR A 149 28.269 52.815 71.656 1.00 26.82 O
ATOM 538 N PHE A 150 31.472 47.568 70.520 1.00 21.16 N
ATOM 539 CA PHE A 150 30.409 46.656 70.128 1.00 21.57 C
ATOM 540 C PHE A 150 28.988 47.214 70.228 1.00 24.70 C
ATOM 541 O PHE A 150 28.015 46.497 69.995 1.00 28.63 O
ATOM 542 CB PHE A 150 30.533 45.357 70.934 1.00 20.32 C
ATOM 543 CG PHE A 150 31.586 44.411 70.406 1.00 17.30 C
ATOM 544 CD1 PHE A 150 32.917 44.798 70.331 1.00 19.04 C
ATOM 545 CD2 PHE A 150 31.246 43.121 70.005 1.00 21.72 C
ATOM 546 CE1 PHE A 150 33.899 43.916 69.867 1.00 19.49 C
ATOM 547 CE2 PHE A 150 32.220 42.228 69.541 1.00 18.80 C
ATOM 548 CZ PHE A 150 33.547 42.626 69.473 1.00 20.01 C
ATOM 549 N GLY A 151 28.870 48.490 70.575 1.00 25.06 N
ATOM 550 CA GLY A 151 27.566 49.123 70.660 1.00 23.63 C
ATOM 551 C GLY A 151 26.526 48.516 71.580 1.00 26.20 C
ATOM 552 O GLY A 151 26.778 48.284 72.764 1.00 26.03 O
ATOM 553 N LYS A 152 25.348 48.261 71.014 1.00 28.61 N
ATOM 554 CA LYS A 152 24.204 47.711 71.741 1.00 34.04 C
ATOM 555 C LYS A 152 24.133 46.181 71.893 1.00 36.21 C
ATOM 556 O LYS A 152 23.158 45.553 71.473 1.00 40.19 O
ATOM 557 CB LYS A 152 22.906 48.213 71.092 1.00 35.93 C
ATOM 558 CG LYS A 152 21.708 48.259 72.023 1.00 43.19 C
ATOM 559 CD LYS A 152 20.709 47.151 71.700 1.00 48.06 C
ATOM 560 CE LYS A 152 19.316 47.471 72.244 1.00 51.14 C
ATOM 561 NZ LYS A 152 19.168 47.079 73.676 1.00 52.84 N
ATOM 562 N ILE A 153 25.161 45.586 72.493 1.00 36.67 N
ATOM 563 CA ILE A 153 25.184 44.144 72.732 1.00 31.15 C
ATOM 564 C ILE A 153 24.892 43.967 74.224 1.00 30.92 C
ATOM 565 O ILE A 153 25.364 44.753 75.055 1.00 32.14 O
ATOM 566 CB ILE A 153 26.568 43.522 72.377 1.00 25.12 C
ATOM 567 CG1 ILE A 153 26.492 41.994 72.476 1.00 27.06 C
ATOM 568 CG2 ILE A 153 27.647 44.056 73.300 1.00 24.60 C
ATOM 569 CD1 ILE A 153 27.837 41.290 72.360 1.00 25.42 C
ATOM 570 N THR A 154 24.095 42.962 74.564 1.00 29.11 N
ATOM 571 CA THR A 154 23.755 42.726 75.962 1.00 29.91 C
ATOM 572 C THR A 154 24.971 42.246 76.755 1.00 28.88 C
ATOM 573 O THR A 154 26.023 41.942 76.187 1.00 28.19 O
ATOM 574 CB THR A 154 22.627 41.683 76.091 1.00 27.54 C
ATOM 575 OG1 THR A 154 23.106 40.407 75.661 1.00 29.22 O
ATOM 576 CG2 THR A 154 21.442 42.073 75.230 1.00 30.72 C
ATOM 577 N ARG A 155 24.828 42.189 78.074 1.00 28.96 N
ATOM 578 CA ARG A 155 25.917 41.736 78.929 1.00 28.83 C
ATOM 579 C ARG A 155 26.134 40.237 78.723 1.00 25.85 C
ATOM 580 O ARG A 155 27.270 39.761 78.708 1.00 24.98 O
ATOM 581 CB ARG A 155 25.591 42.028 80.398 1.00 29.72 C
ATOM 582 CG ARG A 155 26.184 41.033 81.375 1.00 34.40 C
ATOM 583 CD ARG A 155 25.618 41.240 82.757 1.00 36.96 C
ATOM 584 NE ARG A 155 26.001 42.542 83.278 1.00 38.95 N
ATOM 585 CZ ARG A 155 26.984 42.735 84.148 1.00 39.78 C
ATOM 586 NH1 ARG A 155 27.687 41.705 84.600 1.00 38.41 N
ATOM 587 NH2 ARG A 155 27.264 43.960 84.564 1.00 39.61 N
ATOM 588 N ARG A 156 25.041 39.498 78.558 1.00 24.08 N
ATOM 589 CA ARG A 156 25.120 38.056 78.346 1.00 23.47 C
ATOM 590 C ARG A 156 25.841 37.722 77.026 1.00 22.51 C
ATOM 591 O ARG A 156 26.757 36.895 76.987 1.00 17.26 O
ATOM 592 CB ARG A 156 23.702 37.466 78.370 1.00 26.31 C
ATOM 593 CG ARG A 156 23.486 36.213 77.534 1.00 34.48 C
ATOM 594 CD ARG A 156 24.047 34.952 78.199 1.00 43.08 C
ATOM 595 NE ARG A 156 23.734 34.848 79.625 1.00 47.10 N
ATOM 596 CZ ARG A 156 23.173 33.783 80.199 1.00 47.32 C
ATOM 597 NH1 ARG A 156 22.851 32.715 79.476 1.00 41.21 N
ATOM 598 NH2 ARG A 156 22.942 33.783 81.505 1.00 48.21 N