As a future alternative to jQuery, we are experimenting with Web Components version of Handsontable (see demo page for more details).
To use the current experimental version, just load the Toolkitchen Toolkit library and import x-handsontable.html component.
<!-- 1. Load Toolkitchen Toolkit library -->
<script src="toolkit/platform/platform.js"></script>
<!-- 2. Load the component -->
<link rel="import" href="../dist_wc/x-handsontable.html">
<!-- 3. Load a Numeral.js locale if you use numeric cell type -->
<script src="../lib/numeral.de-de.js"></script>