diff --git a/lib/Doctrine/ORM/AbstractQuery.php b/lib/Doctrine/ORM/AbstractQuery.php
index 12adf2d07d8..7ca5f51ca19 100644
--- a/lib/Doctrine/ORM/AbstractQuery.php
+++ b/lib/Doctrine/ORM/AbstractQuery.php
@@ -525,7 +525,7 @@ public function getHydrationCacheProfile()
      */
     public function setResultCacheProfile(QueryCacheProfile $profile = null)
     {
-        if ( ! $profile->getResultCacheDriver()) {
+        if ($profile !== null && ! $profile->getResultCacheDriver()) {
             $resultCacheDriver = $this->_em->getConfiguration()->getResultCacheImpl();
             $profile = $profile->setResultCacheDriver($resultCacheDriver);
         }
diff --git a/tests/Doctrine/Tests/ORM/Query/QueryTest.php b/tests/Doctrine/Tests/ORM/Query/QueryTest.php
index 2703ccf034b..d18a263c596 100644
--- a/tests/Doctrine/Tests/ORM/Query/QueryTest.php
+++ b/tests/Doctrine/Tests/ORM/Query/QueryTest.php
@@ -5,6 +5,7 @@
 use Doctrine\Common\Cache\ArrayCache;
 use Doctrine\Common\Collections\ArrayCollection;
 
+use Doctrine\DBAL\Cache\QueryCacheProfile;
 use Doctrine\ORM\EntityManager;
 use Doctrine\ORM\Query\Parameter;
 
@@ -259,4 +260,18 @@ public function testSetParameterWithTypeJugglingWorks()
         self::assertSame(3, $query->getParameter('0')->getValue());
         self::assertSame('Doctrine', $query->getParameter('name')->getValue());
     }
+
+    /**
+     * @group 6748
+     */
+    public function testResultCacheProfileCanBeRemovedViaSetter()
+    {
+        $this->_em->getConfiguration()->setResultCacheImpl(new ArrayCache());
+
+        $query = $this->_em->createQuery('SELECT u FROM Doctrine\Tests\Models\CMS\CmsUser u');
+        $query->useResultCache(true);
+        $query->setResultCacheProfile();
+
+        self::assertAttributeSame(null, '_queryCacheProfile', $query);
+    }
 }