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Release 2.2-r409 (17 September 2017)

This is a feature release. It improves single-end short-read alignment and comes with Python bindings. Detailed changes include:

  • Added the sr preset for single-end short-read alignment. In this mode, minimap2 runs faster than BWA-MEM, but is slightly less accurate on simulated data sets. Paired-end alignment is not supported as of now.

  • Improved mapping quality estimate with more accurate identification of repetitive hits. This mainly helps short-read alignment.

  • Implemented mappy, a Python binding for minimap2, which is available from PyPI and can be installed with pip install --user mappy. Python users can perform read alignment without the minimap2 executable.

  • Restructured the indexing APIs and documented key minimap2 APIs in the header file minimap.h. Updated example.c with the new APIs. Old APIs still work but may become deprecated in future.

This release may output alignments different from the previous version, though the overall alignment statistics, such as the number of aligned bases and long gaps, remain close.

(2.2: 17 September 2017, r409)

Release 2.1.1-r341 (6 September 2017)

This is a maintenance release that is expected to output identical alignment to v2.1. Detailed changes include:

  • Support CPU dispatch. By default, minimap2 is compiled with both SSE2 and SSE4 based implementation of alignment and automatically chooses the right one at runtime. This avoids unexpected errors on older CPUs (#21).

  • Improved Windows support as is requested by Oxford Nanopore (#19). Minimap2 now avoids variable-length stacked arrays, eliminates alloca(), ships with getopt_long() and provides timing functions implemented with Windows APIs.

  • Fixed a potential segmentation fault when specifying -k/-w/-H with multi-part index (#23).

  • Fixed two memory leaks in example.c

(2.1.1: 6 September 2017, r341)

Release 2.1-r311 (25 August 2017)

This release adds spliced alignment for long noisy RNA-seq reads. On a SMRT Iso-Seq and a Oxford Nanopore data sets, minimap2 appears to outperform traditional mRNA aligners. For DNA alignment, this release gives almost identical output to v2.0. Other changes include:

  • Added option -R to set the read group header line in SAM.

  • Optionally output the cs:Z tag in PAF to encode both the query and the reference sequences in the alignment.

  • Fixed an issue where DP alignment uses excessive memory.

The minimap2 technical report has been updated with more details and the evaluation of spliced alignment:

  • Li, H. (2017). Minimap2: fast pairwise alignment for long nucleotide sequences. arXiv:1708.01492v2.

(2.1: 25 August 2017, r311)

Release 2.0-r275 (8 August 2017)

This release is identical to version 2.0rc1, except the version number. It is described and evaluated in the following technical report:

  • Li, H. (2017). Minimap2: fast pairwise alignment for long DNA sequences. arXiv:1708.01492v1.

(2.0: 8 August 2017, r275)

Release 2.0rc1-r232 (30 July 2017)

This release improves the accuracy of long-read alignment and added several minor features.

  • Improved mapping quality estimate for short alignments containing few seed hits.

  • Fixed a minor bug that affects the chaining accuracy towards the ends of a chain. Changed the gap cost for chaining to reduce false seeding.

  • Skip potentially wrong seeding and apply dynamic programming more frequently. This slightly increases run time, but greatly reduces false long gaps.

  • Perform local alignment at Z-drop break point to recover potential inversion alignment. Output the SA tag in the SAM format. Added scripts to evaluate mapping accuracy for reads simulated with pbsim.

This release completes features intended for v2.0. No major features will be added to the master branch before the final v2.0.

(2.0rc1: 30 July 2017, r232)

Release r191 (19 July 2017)

This is the first public release of minimap2, an aligner for long reads and assemblies. This release has a few issues and is generally not recommended for production uses.

(19 July 2017, r191)