susieR

The susieR package implements a simple new way to perform variable selection in multiple regression ($y=Xb+e$). The methods implemented here are particularly well-suited to settings where some of the X variables are highly correlated, and the true effects are highly sparse (e.g. <20 non-zero effects in the vector $b$). One example of this is genetic fine-mapping applications, and this application was a major motivation for developing these methods. However, the methods should also be useful more generally.

The methods are based on a new model for sparse multiple regression, which we call the "Sum of Single Effects" (SuSiE) model. This model, which will be described in a manuscript in preparation (Wang et al), lends itself to a particularly simple and intuitive fitting procedure -- effectively a Bayesian modification of simple forward selection, which we call "Iterative Bayesian Step-wise Selection".

The output of the fitting procedure is a number of "Credible Sets" (CSs), which are each designed to have high probability to contain a variable with non-zero effect, while at the same time being as small as possible. You can think of the CSs as being a set of "highly correlated" variables that are each associated with the response: you can be confident that one of the variables has a non-zero coefficient, but they are too correlated to be sure which one.

The package is developed by Gao Wang, Peter Carbonetto, Yuxin Zou, Kaiqian Zhang, and Matthew Stephens from the Stephens Lab at the University of Chicago.

Please post issues to ask questions, get our support or provide us feedback; please send pull requests if you have helped fixing bugs or making improvements to the source code.

Quick Start

Install susieR from CRAN:

install.packages("susieR")

Alternatively, install the latest development version of susieR from GitHub:

# install.packages("remotes")
remotes::install_github("stephenslab/susieR")

See here for a brief illustration of susieR. For more documentation and examples please visit https://stephenslab.github.io/susieR

Citing this work

If you find the susieR package or any of the source code in this repository useful for your work, please cite:

G. Wang, G., Sarkar, A., Carbonetto, P. & Stephens, M. (2020). A simple new approach to variable selection in regression, with application to genetic fine mapping. Journal of the Royal Statistical Society, Series B 82, 1273–1300. https://doi.org/10.1111/rssb.12388

If you use any of the summary data methods such as susie_suff_stat or susie_rss, please also cite:

Zou, Y., Carbonetto, P., Wang, G. & Stephens, M. (2022). Fine-mapping from summary data with the "Sum of Single Effects" model. PLoS Genetics 18, e1010299. https://doi.org/10.1371/journal.pgen.1010299

Developer notes

• When any changes are made to roxygen2 markup, run devtools::document() to update package NAMESPACE and documentation files.

• Run pkgdown::build_site() to build the website. Getting pkgdown to work properly can be frustrating due to numerous & fragile dependencies. If pkgdown does not work for you out of the box you can use this docker command to run all vignettes and build the site:

docker run --rm --security-opt label:disable -t -P -w $PWD -v $PWD:$PWD \
  -u $UID:${GROUPS[0]} -e HOME=/home/$USER -e USER=$USER gaow/susie \
  R --slave -e "pkgdown::build_site(lazy=TRUE, examples=FALSE)"