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variant: markdown_github | ||
variant: gfm | ||
html_preview: false | ||
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DOSE: Disease Ontology Semantic and Enrichment analysis | ||
======================================================= | ||
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[![](https://img.shields.io/badge/release%20version-3.4.0-green.svg)](https://bioconductor.org/packages/DOSE) [![](https://img.shields.io/badge/devel%20version-3.5.1-green.svg)](https://github.com/guangchuangyu/DOSE) [![Bioc](http://www.bioconductor.org/shields/years-in-bioc/DOSE.svg)](https://www.bioconductor.org/packages/devel/bioc/html/DOSE.html#since) | ||
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[![platform](http://www.bioconductor.org/shields/availability/devel/DOSE.svg)](https://www.bioconductor.org/packages/devel/bioc/html/DOSE.html#archives) [![Build Status](http://www.bioconductor.org/shields/build/devel/bioc/DOSE.svg)](https://bioconductor.org/checkResults/devel/bioc-LATEST/DOSE/) [![Linux/Mac Travis Build Status](https://img.shields.io/travis/GuangchuangYu/DOSE/master.svg?label=Mac%20OSX%20%26%20Linux)](https://travis-ci.org/GuangchuangYu/DOSE) [![AppVeyor Build Status](https://img.shields.io/appveyor/ci/Guangchuangyu/DOSE/master.svg?label=Windows)](https://ci.appveyor.com/project/GuangchuangYu/DOSE) | ||
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[![Project Status: Active - The project has reached a stable, usable state and is being actively developed.](http://www.repostatus.org/badges/latest/active.svg)](http://www.repostatus.org/#active) [![codecov](https://codecov.io/gh/GuangchuangYu/DOSE/branch/master/graph/badge.svg)](https://codecov.io/gh/GuangchuangYu/DOSE/) [![Last-changedate](https://img.shields.io/badge/last%20change-2018--04--09-green.svg)](https://github.com/GuangchuangYu/DOSE/commits/master) | ||
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This package implements five methods proposed by *Resnik*, *Schlicker*, *Jiang*, *Lin* and *Wang* respectively for measuring semantic similarities among DO terms and gene products. Enrichment analyses including hypergeometric model and gene set enrichment analysis are also implemented for discovering disease associations of high-throughput biological data. | ||
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For details, please visit our project website, <https://guangchuangyu.github.io/software/DOSE>. | ||
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- [Documentation](https://guangchuangyu.github.io/software/DOSE/documentation/) | ||
- [Featured Articles](https://guangchuangyu.github.io/software/DOSE/featuredArticles/) | ||
- [Feedback](https://guangchuangyu.github.io/software/DOSE/#feedback) | ||
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[![Twitter](https://img.shields.io/twitter/url/http/shields.io.svg?style=social&logo=twitter)](https://twitter.com/intent/tweet?hashtags=DOSE&url=http://bioinformatics.oxfordjournals.org/content/31/4/608) [![saythanks](https://img.shields.io/badge/say-thanks-ff69b4.svg)](https://saythanks.io/to/GuangchuangYu) [![](https://img.shields.io/badge/follow%20me%20on-微信-green.svg)](https://guangchuangyu.github.io/blog_images/biobabble.jpg) [![](https://img.shields.io/badge/打赏-支付宝/微信-green.svg)](https://guangchuangyu.github.io/blog_images/pay_qrcode.png) | ||
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------------------------------------------------------------------------ | ||
# DOSE: Disease Ontology Semantic and Enrichment analysis | ||
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[![releaseVersion](https://img.shields.io/badge/release%20version-3.6.1-green.svg?style=flat)](https://bioconductor.org/packages/DOSE) | ||
[![develVersion](https://img.shields.io/badge/devel%20version-3.7.1-green.svg?style=flat)](https://github.com/guangchuangyu/DOSE) | ||
[![Bioc](http://www.bioconductor.org/shields/years-in-bioc/DOSE.svg)](https://www.bioconductor.org/packages/devel/bioc/html/DOSE.html#since) | ||
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[![platform](http://www.bioconductor.org/shields/availability/devel/DOSE.svg)](https://www.bioconductor.org/packages/devel/bioc/html/DOSE.html#archives) | ||
[![Build | ||
Status](http://www.bioconductor.org/shields/build/devel/bioc/DOSE.svg)](https://bioconductor.org/checkResults/devel/bioc-LATEST/DOSE/) | ||
[![Linux/Mac Travis Build | ||
Status](https://img.shields.io/travis/GuangchuangYu/DOSE/master.svg?label=Mac%20OSX%20%26%20Linux)](https://travis-ci.org/GuangchuangYu/DOSE) | ||
[![AppVeyor Build | ||
Status](https://img.shields.io/appveyor/ci/Guangchuangyu/DOSE/master.svg?label=Windows)](https://ci.appveyor.com/project/GuangchuangYu/DOSE) | ||
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[![Project Status: Active - The project has reached a stable, usable | ||
state and is being actively | ||
developed.](http://www.repostatus.org/badges/latest/active.svg)](http://www.repostatus.org/#active) | ||
[![codecov](https://codecov.io/gh/GuangchuangYu/DOSE/branch/master/graph/badge.svg)](https://codecov.io/gh/GuangchuangYu/DOSE/) | ||
[![Last-changedate](https://img.shields.io/badge/last%20change-2018--09--30-green.svg)](https://github.com/GuangchuangYu/DOSE/commits/master) | ||
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This package implements five methods proposed by *Resnik*, *Schlicker*, | ||
*Jiang*, *Lin* and *Wang* respectively for measuring semantic | ||
similarities among DO terms and gene products. Enrichment analyses | ||
including hypergeometric model and gene set enrichment analysis are also | ||
implemented for discovering disease associations of high-throughput | ||
biological data. | ||
|
||
For details, please visit our project website, | ||
<https://guangchuangyu.github.io/software/DOSE>. | ||
|
||
- [Documentation](https://guangchuangyu.github.io/software/DOSE/documentation/) | ||
- [Featured | ||
Articles](https://guangchuangyu.github.io/software/DOSE/featuredArticles/) | ||
- [Feedback](https://guangchuangyu.github.io/software/DOSE/#feedback) | ||
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[![Twitter](https://img.shields.io/twitter/url/http/shields.io.svg?style=social&logo=twitter)](https://twitter.com/intent/tweet?hashtags=DOSE&url=http://bioinformatics.oxfordjournals.org/content/31/4/608) | ||
[![saythanks](https://img.shields.io/badge/say-thanks-ff69b4.svg)](https://saythanks.io/to/GuangchuangYu) | ||
[![](https://img.shields.io/badge/follow%20me%20on-微信-green.svg?style=flat)](https://guangchuangyu.github.io/blog_images/biobabble.jpg) | ||
[![](https://img.shields.io/badge/打赏-支付宝/微信-green.svg?style=flat)](https://guangchuangyu.github.io/blog_images/pay_qrcode.png) | ||
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----- | ||
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Please cite the following article when using `DOSE`: | ||
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***G Yu***, LG Wang, GR Yan, QY He. DOSE: an R/Bioconductor package for Disease Ontology Semantic and Enrichment analysis. ***Bioinformatics*** 2015, 31(4):608-609. | ||
***G Yu***, LG Wang, GR Yan, QY He. DOSE: an R/Bioconductor package for | ||
Disease Ontology Semantic and Enrichment analysis. ***Bioinformatics*** | ||
2015, | ||
31(4):608-609. | ||
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[![](https://img.shields.io/badge/doi-10.1093/bioinformatics/btu684-green.svg)](http://dx.doi.org/10.1093/bioinformatics/btu684) [![](https://img.shields.io/badge/Altmetric-26-green.svg)](https://www.altmetric.com/details/2788597) | ||
[![doi](https://img.shields.io/badge/doi-10.1093/bioinformatics/btu684-green.svg?style=flat)](http://dx.doi.org/10.1093/bioinformatics/btu684) | ||
[![Altmetric](https://img.shields.io/badge/Altmetric-26-green.svg?style=flat)](https://www.altmetric.com/details/2788597) | ||
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------------------------------------------------------------------------ | ||
----- | ||
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### Citation | ||
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<img src="https://guangchuangyu.github.io/software/DOSE/featured-articles/index_files/figure-html/citation-1.png" width="890"/> | ||
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### Download stats | ||
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[![download](http://www.bioconductor.org/shields/downloads/DOSE.svg)](https://bioconductor.org/packages/stats/bioc/DOSE) [![](https://img.shields.io/badge/download-65637/total-blue.svg)](https://bioconductor.org/packages/stats/bioc/DOSE) [![](https://img.shields.io/badge/download-2907/month-blue.svg)](https://bioconductor.org/packages/stats/bioc/DOSE) | ||
[![download](http://www.bioconductor.org/shields/downloads/DOSE.svg)](https://bioconductor.org/packages/stats/bioc/DOSE) | ||
[![total](https://img.shields.io/badge/downloads-85376/total-blue.svg?style=flat)](https://bioconductor.org/packages/stats/bioc/DOSE) | ||
[![month](https://img.shields.io/badge/downloads-3396/month-blue.svg?style=flat)](https://bioconductor.org/packages/stats/bioc/DOSE) | ||
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<img src="https://guangchuangyu.github.io/software/DOSE/index_files/figure-html/dlstats-1.png" width="890"/> |
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--- | ||
title: "Disease Ontology Semantic and Enrichment analysis" | ||
author: "\\ | ||
author: "Guangchuang Yu\\ | ||
Guangchuang Yu (<[email protected]>)\\ | ||
School of Public Health, The University of Hong Kong" | ||
School of Basic Medical Sciences, Southern Medical University" | ||
date: "`r Sys.Date()`" | ||
bibliography: DOSE.bib | ||
csl: nature.csl | ||
biblio-style: apalike | ||
output: | ||
BiocStyle::html_document: | ||
prettydoc::html_pretty: | ||
toc: true | ||
BiocStyle::pdf_document: | ||
theme: cayman | ||
highlight: github | ||
pdf_document: | ||
toc: true | ||
vignette: > | ||
%\VignetteIndexEntry{00 DOSE introduction} | ||
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@@ -22,17 +22,27 @@ vignette: > | |
--- | ||
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```{r style, echo=FALSE, results="asis", message=FALSE} | ||
BiocStyle::markdown() | ||
knitr::opts_chunk$set(tidy = FALSE, | ||
warning = FALSE, | ||
message = FALSE) | ||
CRANpkg <- function (pkg) { | ||
cran <- "https://CRAN.R-project.org/package" | ||
fmt <- "[%s](%s=%s)" | ||
sprintf(fmt, pkg, cran, pkg) | ||
} | ||
Biocpkg <- function (pkg) { | ||
sprintf("[%s](http://bioconductor.org/packages/%s)", pkg, pkg) | ||
} | ||
``` | ||
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```{r echo=FALSE, results='hide', message=FALSE} | ||
library(DOSE) | ||
``` | ||
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Disease Ontology (DO)[@schriml_disease_2011] aims to provide an open source ontology for the integration of biomedical data that is associated with human disease. | ||
We developed `r Biocpkg("DOSE")`[@yu_dose_2015] package to promote the investigation of diseases. `r Biocpkg("DOSE")` provides five methods including _Resnik_, _Lin_, _Jiang_, _Rel_ and _Wang_ for measuring semantic similarities among DO terms and gene products; Hypergeometric model and Gene Set Enrichment Analysis (GSEA) were also implemented for extracting disease association insight from genome wide expression profiles. | ||
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@@ -72,8 +82,6 @@ to [Bioconductor support site](https://support.bioconductor.org/) and tag your | |
post with *DOSE*. | ||
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For Chinese user, you can follow me on [WeChat (微信)](https://guangchuangyu.github.io/blog_images/biobabble.jpg). | ||
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# Session Information | ||
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|
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---|---|---|
@@ -1,17 +1,17 @@ | ||
--- | ||
title: "Disease Gene Set Enrichment Analysis" | ||
author: "\\ | ||
author: "Guangchuang Yu\\ | ||
Guangchuang Yu (<[email protected]>)\\ | ||
School of Public Health, The University of Hong Kong" | ||
School of Basic Medical Sciences, Southern Medical University" | ||
date: "`r Sys.Date()`" | ||
bibliography: DOSE.bib | ||
csl: nature.csl | ||
biblio-style: apalike | ||
output: | ||
BiocStyle::html_document: | ||
prettydoc::html_pretty: | ||
toc: true | ||
BiocStyle::pdf_document: | ||
theme: cayman | ||
highlight: github | ||
pdf_document: | ||
toc: true | ||
vignette: > | ||
%\VignetteIndexEntry{03 Disease GSEA} | ||
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@@ -21,10 +21,19 @@ vignette: > | |
--- | ||
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```{r style, echo=FALSE, results="asis", message=FALSE} | ||
BiocStyle::markdown() | ||
knitr::opts_chunk$set(tidy = FALSE, | ||
warning = FALSE, | ||
message = FALSE) | ||
CRANpkg <- function (pkg) { | ||
cran <- "https://CRAN.R-project.org/package" | ||
fmt <- "[%s](%s=%s)" | ||
sprintf(fmt, pkg, cran, pkg) | ||
} | ||
Biocpkg <- function (pkg) { | ||
sprintf("[%s](http://bioconductor.org/packages/%s)", pkg, pkg) | ||
} | ||
``` | ||
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```{r echo=FALSE, results='hide', message=FALSE} | ||
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---|---|---|
@@ -1,17 +1,17 @@ | ||
--- | ||
title: "Disease enrichment analysis" | ||
author: "\\ | ||
author: "Guangchuang Yu\\ | ||
Guangchuang Yu (<[email protected]>)\\ | ||
School of Public Health, The University of Hong Kong" | ||
School of Basic Medical Sciences, Southern Medical University" | ||
date: "`r Sys.Date()`" | ||
bibliography: DOSE.bib | ||
csl: nature.csl | ||
biblio-style: apalike | ||
output: | ||
BiocStyle::html_document: | ||
prettydoc::html_pretty: | ||
toc: true | ||
BiocStyle::pdf_document: | ||
theme: cayman | ||
highlight: github | ||
pdf_document: | ||
toc: true | ||
vignette: > | ||
%\VignetteIndexEntry{02 Disease enrichment analysis} | ||
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@@ -21,10 +21,20 @@ vignette: > | |
--- | ||
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```{r style, echo=FALSE, results="asis", message=FALSE} | ||
BiocStyle::markdown() | ||
knitr::opts_chunk$set(tidy = FALSE, | ||
warning = FALSE, | ||
message = FALSE) | ||
CRANpkg <- function (pkg) { | ||
cran <- "https://CRAN.R-project.org/package" | ||
fmt <- "[%s](%s=%s)" | ||
sprintf(fmt, pkg, cran, pkg) | ||
} | ||
Biocpkg <- function (pkg) { | ||
sprintf("[%s](http://bioconductor.org/packages/%s)", pkg, pkg) | ||
} | ||
``` | ||
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```{r echo=FALSE, results='hide', message=FALSE} | ||
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