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Classification of Medial Entorhinal Units

Grid cells are neurons in the medial entorhinal cortex (MEC) that are activated when the subject passes through multiple locations arranged in a hexagonal grid. Grid cells, along with other cells in the MEC such as head direction and speed cells, form circuits with place cells to create a comprehensive positioning system in the brain.

This project therefore attempts to provide a classification system to identify grid cells located in the medial entorhinal cortex in order to better understand the navigational building blocks necessary for important memory processes.

Features

Canonical Grid Scoring

Performs the established grid scoring methods, which includes analyzing the periodicity of the autocorrelation matrix's correlation curve.

Two-Dimensional Fourier Transformation Scoring

Extracts any significant periodict patterns from the firing rate map by utilizing the properties of two-dimensional Fourier transformations.

Average Annulus Power Component Identification

Identifies significant contributing components of the Fourier spectrogram by calculating the distribution of the average power of pixels within a defined annulus of various radial lengths and comparing this to the random distribution.

Requirements

  • python
  • math
  • numpy
  • scipy
  • matplotlib

Citations

Neuronal data was downloaded from the Kavli Institue for Systems Neuroscience Sargolini et al 2006 data set.

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Classification of medial entorhinal units

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