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Update README to direct users to new pipeline
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esrice committed Sep 30, 2022
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Expand Up @@ -3,6 +3,13 @@ A pipeline for scaffolding a genome assembly using Hi-C and SALSA2,
generalizable to whatever job scheduler or local system you are using. Loosely
based on the [Arima Hi-C mapping pipeline](https://github.com/ArimaGenomics/mapping_pipeline).

*N.B.* (30 September 2022): I have developed a new pipeline for scaffolding with
Hi-C reads. It produces much better results thanks to improved algorithms for
mapping (chromap instead of bwa + postprocessing) and scaffolding (YAHS instead
of SALSA2). I strongly recommend using that one now:

<https://github.com/WarrenLab/hic-scaffolding-nf>

## Options for running
I use [nextflow](https://www.nextflow.io/) to run this pipeline, because it
automatically deals with submitting cluster jobs and containerization. You can run
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