NTD analysis pipeline version

Antibody Analysis - IgPipeline 2

This is modified version of the original IgPipeline, allowing the use of different isotypes (IgG, IgM and IgA). It was first used in the following publication:

• Wang Z, Lorenzi JCC, Muecksch F, et al. Enhanced SARS-CoV-2 neutralization by dimeric IgA. Sci Transl Med. 2021;13(577):eabf1555. doi:10.1126/scitranslmed.abf1555

The same pipeline was used to analyze antibody evolution between two timepoints as described in our publication:

• Gaebler C, Wang Z, Lorenzi JCC, et al. Evolution of antibody immunity to SARS-CoV-2. Nature. 2021;10.1038/s41586-021-03207-w. doi:10.1038/s41586-021-03207-w

Sequences from timepoints 1.3 months and 6.2 months were placed in the IgG and IgM slots of this pipeline,and the figures labels were modified manually using Adobe Illustrator.

igpipeline2_timepoint_v2

Antibody Analysis - IgPipeline 2

This is modified version of the original IgPipeline, allowing the use of different isotypes (IgG, IgM and IgA). It was first used in the following publication:

• Wang Z, Lorenzi JCC, Muecksch F, et al. Enhanced SARS-CoV-2 neutralization by dimeric IgA. Sci Transl Med. 2021;13(577):eabf1555. doi:10.1126/scitranslmed.abf1555

The same pipeline was used to analyze antibody evolution between two timepoints as described in our publication:

• Gaebler C, Wang Z, Lorenzi JCC, et al. Evolution of antibody immunity to SARS-CoV-2. Nature. 2021;10.1038/s41586-021-03207-w. doi:10.1038/s41586-021-03207-w

Sequences from timepoints 1.3 months and 6.2 months were placed in the IgG and IgM slots of this pipeline,and the figures labels were modified manually using Adobe Illustrator.